REVIEW article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
This article is part of the Research TopicFunctional Biomaterials and Seed Cells in Tissue EngineeringView all 11 articles
Biomimetic materials: A promising strategy for periodontal tissue engineering and regeneration
Provisionally accepted
- Chengdu Medical College, Chengdu, China
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Abstract Periodontitis is a chronic inflammatory disorder that causes irreversible damage to periodontal tissues, such as the alveolar bone, cementum, and periodontal ligament. Clinical treatments for periodontitis include non-surgical and surgical approaches, complemented by the utilization of various biomimetic materials to repair damaged tissues, a process known as periodontal tissue regeneration. Biomimetic materials have demonstrated extensive application prospects in periodontal tissue regeneration owing to their outstanding biocompatibility, controllable mechanical properties, and biomimetic microstructures. This review begins by delineating the cells uzed in periodontal tissue regeneration, and summarizes the applications and research hotspots of commonly employed biomaterials in periodontal tissues. This further highlights the advantages of using biomimetic materials as bone substitutes, barrier membranes, and complex scaffold-manufacturing techniques. In addition, an in-depth discussion is conducted on its biological safety and physical properties. Moreover, this article summarizes the research advancements of extracellular matrix (ECM) materials in periodontal tissues, which hold great promise as highly prospective biomaterials for periodontal tissue regeneration. Finally, this article provides a comprehensive summary of the current limitations and challenges associated with the application of biomaterials in periodontal tissue This is a provisional file, not the final typeset article regeneration. Although biomimetic materials still encounter challenges regarding stability and long-term efficacy during clinical translation, this review offers insights into basic research and clinical treatment of periodontal regeneration.
Keywords: Periodontal tissues regeneration, Guided Tissue Regeneration, biomaterial materials, Tissue Engineering, Extracellular Matrix
Received: 01 Jun 2025; Accepted: 06 Oct 2025.
Copyright: © 2025 Zhang, Gou and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhijun Zhang, zhangzhijun@cmc.edu.cn
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