REVIEW article
Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1645657
Functionalized Metal-Organic Framework (MOF) and MOF-Derived Materials for Bone Regeneration Application
Provisionally accepted
- 1Chongqing Medical University, Chongqing, China
- 2Bishan Hospital of Chongqing Medical University, Chongqing, China
- 3Army Medical University Daping Hospital Thoracic Surgery Department, Chongqing, China
- 4The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Bone defects resulting from trauma, tumors, infections, and aging present significant clinical challenges, with conventional grafts hindered by limitations in biocompatibility, mechanical strength, and integration. Metal-organic frameworks (MOFs), as advanced nanomaterials with tunable porosity, high surface area, and stimuli-responsive properties, hold immense potential for bone regeneration. This review provides a comprehensive overview of the classification, synthesis methods, osteogenic mechanisms, and applications of functionalized MOFs and their derivatives in bone repair. MOFs are classified based on structural topology, chemical composition, and functional applications. Synthesis techniques, including solvothermal, ultrasonic, and electrochemical approaches, are evaluated for customizing physical properties such as pore architecture and stability. Osteogenic mechanisms encompass enhancing implant physical characteristics to promote cell adhesion, sustained release of metal ions to activate signaling pathways, controlled drug delivery for targeted therapy, and anti-inflammatory/antioxidant effects through reactive oxygen species scavenging. Applications address various bone pathologies, demonstrating improved angiogenesis, osteointegration, and antibacterial performance in preclinical studies. Key challenges, including cytotoxicity, long-term biosafety, and scalability, are discussed, alongside strategies like surface modification and hybrid composites to overcome these barriers. Future perspectives focus on developing smart MOF-based scaffolds for personalized regenerative medicine, underscoring their transformative potential in orthopedic therapies.
Keywords: Metal-organic framework (MOF), nanomaterials, Bone Regeneration, Bone repair, biomaterials To date, many MOFs have been designed, with PCN, MIL, Zeolitic Imidazolate
Received: 12 Jun 2025; Accepted: 12 Aug 2025.
Copyright: © 2025 Fan, Long, Cai, Hu and Peng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yingkun Hu, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Lihua Peng, Bishan Hospital of Chongqing Medical University, Chongqing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.