REVIEW article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1646629
Biomaterials strategy for promoting palatal wound healing
Provisionally accepted
- 1School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China
- 2School and Hospital of Stomatology Wenzhou Medical University Department of Oral Maxillofacial Surgery, Wenzhou, China
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Palatal wounds arising from trauma, tumors, cleft palate, or free gingival grafting (FGG) and other etiologies compromise critical orofacial functions including mastication, deglutition phonation and articulation, while posing life-threatening risks in severe conditions. Although surgical resection remains the primary clinical intervention, current treatment strategies for palatal injuries are constrained by several limitations, including: bacterial contamination and chronic inflammation, extensive soft tissue defects, postoperative scar formation, compromised blood supply in the surgical field, and potential patient comorbidities. Research on wound healing based on biomaterials has advanced substantially in recent decades, significantly facilitating their application in tissue engineering. This review provides a comprehensive overview of biomaterials used in palatal wounds, including acellular dermal matrix (ADM), platelet-rich derivatives (e.g. PRF, PRP), amniotic membrane, growth factor, hyaluronic acid, collagen, novel hydrogel, nanofiber scaffolds and other relevant materials. It further discusses potential mechanisms that may be involved in palatal wound healing. The objectives of this review are to summarize recent advances in preclinical and clinical studies on biomaterials for palatal wound healing and to highlight their therapeutic potential in this context.
Keywords: palate wound healing, Biomaterials, Treatment, Oxidative Stress, Inflammation
Received: 13 Jun 2025; Accepted: 23 Jul 2025.
Copyright: © 2025 Tong, Ren, Yao, Wang, Hong and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shufan Zhao, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China
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