ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1647678
This article is part of the Research TopicMetallic Biomaterials for Medical Applications - Volume IIView all 4 articles
3D-Printed Copper-Containing Tailored Titanium Alloys with Corrosion Resistance, Biocompatibility and Anti-Inflammatory Properties for Enhanced Guided Bone Regeneration
Provisionally accepted
- 1Fujian Medical University, Fuzhou, China
- 2Fujian Normal University, Fuzhou, China
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This investigation systematically evaluates the microstructure and biological properties of 6, 8 wt%) alloys were produced using selective laser melting for their potential use in guided bone regeneration. Microstructural analysis revealed that increasing Cu content enhanced Ti₂Cu precipitation within the α-Ti matrix. While the increased Cu content did not compromise the corrosion resistance, it did result in a higher Cu ions concentration releasing. Antibacterial assays demonstrated that alloys having a Cu content in excess of 4 wt% showed exhibited >90% bacterial reduction (S.aureus and E. coli). In vitro, Ti-6Cu optimally promoted osteoblast proliferation and upregulated osteogenic genes (Alp, Col-1). Furthermore, Ti-6Cu can upregulate pro-anti-inflammatory factors (Il-10, Arg-1) expression while downregulating inflammatory factors . The study established SLM-treated antibacterial Ti-6Cu alloy exhibited favorable biological activity, demonstrating promising potential for application in regeneration scaffolds.
Keywords: Ti-Cu alloy 1, corrosion resistance 2, biocompatibility 3, anti-inflammatory 4, osteogenesis 5
Received: 16 Jun 2025; Accepted: 23 Jul 2025.
Copyright: © 2025 Luo, Zhong, Chen, Wu, Li, Xue, Lu, Luo and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Kai Luo, Fujian Medical University, Fuzhou, China
Wei Zhao, Fujian Medical University, Fuzhou, China
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