ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Nanobiotechnology
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1648167
This article is part of the Research TopicAdvancements in Nanomedicine for Targeted Cancer Therapy and ImagingView all 7 articles
Sonodynamic and Magnetic Targeting Platelet-Membrane Biomimetic Platform for Glioblastoma Therapy
Provisionally accepted
- 1Chengdu Second People's Hospital, Chengdu, China
- 2Public Health Clinical Center of Chengdu, Chengdu, China
- 3Sichuan Province Orthopedic Hospital, Chengdu, China
- 4Sichuan Cancer Hospital and Institute, Chengdu, China
- 5University of Electronic Science and Technology of China, Chengdu, China
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Background: Due to the presence of the blood-brain barrier, the efficacy of chemotherapy for glioblastoma has remained suboptimal. Even drugs capable of crossing the BBB, such as temozolomide, exhibit limited therapeutic outcomes owing to insufficient targeting. Methods: Here, we developed a platelet membrane-hybridized biomimetic microbubble by loading superparamagnetic iron oxide and temozolomide-embedded polymers, constructing an ultrasound-controlled platelet membrane-inspired magnetic targeting drug delivery platform (ST-PM). Extensive in vitro and in vivo experimental results demonstrate that ST-PM exhibits inhibitory effects on glioblastoma under the combined action of a magnetic field and focused ultrasound. Results: The results demonstrated that ST-PM significantly enhanced microbubble stability in vivo while preserving both the magnetic targeting capability of magnetic drugs and the ultrasound-sensitizing properties of microbubbles. In orthotopic tumor mouse models, ST-PM exhibited superior tumor-targeting efficiency and markedly inhibited tumor growth. Furthermore, H&E staining of major organs confirmed the biosafety of ST-PM. Conclusions: The platelet membrane enhances the stability of drug-loaded microbubbles, facilitating targeted drug accumulation at the lesion site. These findings propose a novel treatment strategy with clinical translation potential for glioblastoma management.
Keywords: focused ultrasound, Platelet, Microbubble, magnetic targeting, Glioblastoma
Received: 16 Jun 2025; Accepted: 01 Sep 2025.
Copyright: © 2025 Zou, Zhang, Mao, Yuan and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jie Yang, Sichuan Cancer Hospital and Institute, Chengdu, China
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