ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biosensors and Biomolecular Electronics
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1648347
This article is part of the Research TopicIntegration of Next-Generation Technologies with Biosensors for Advanced Diagnostics and Personalized MedicineView all 3 articles
Quantitative absorptive micro-sampling for decentralized monitoring of insulin-like growth factor 1
Provisionally accepted
- Peking Union Medical College Hospital (CAMS), Beijing, China
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This study establishes a novel quantitative acoustic mass spectrometry (QAMS) methodology for insulin-like growth factor 1 (IGF-1) detection. Chromatographic separation utilized a Peptide C18 column (1.8 μm, 50 mm) with 0.1% formic acid/acetonitrile gradient elution, coupled to tandem mass spectrometry operated in scheduled multiple reaction monitoring (sMRM) mode. The method demonstrated a lower limit of quantification (LOQ) of 10 ng/mL with linear dynamic range spanning 10-500 ng/mL. Comparative analysis of 74 paired plasma specimens revealed strong inter-matrix correlation with quantifiable bias. These advancements position QAMS-as a robust tool for decentralized IGF-1 monitoring, particularly valuable in pediatric growth disorder studies and resource-limited settings. Longitudinal stability validation and isoform differentiation remain focal points for future optimization.
Keywords: growth hormone deficiency, IGF-1, quantitative absorptionmicro-sampling, Mass Spectrometry, Analytical device
Received: 17 Jun 2025; Accepted: 02 Sep 2025.
Copyright: © 2025 Li, Zhao, Chen, Pan, Guo and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaogang Li, Peking Union Medical College Hospital (CAMS), Beijing, China
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