L5 spondylolysis increases segmental mobility at the cranial adjacent level without altering intervertebral disc contact pressure

Zhilin Ge¹Bingde Zhao²Xu Xu³Lin Chen³Dongzhu Liang⁴Qingyang Kang¹Zibo Gao¹Junhua Luo¹Jiheng Zhan²Jianquan Chen³Bo Zhang^3*

• ¹Guangzhou University of Chinese Medicine, Guangzhou, China
• ²Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
• ³Guangdong Provincial Hospital of Chinese Medicine Zhuhai, Zhuhai, China
• ⁴Guangdong Provincial Key Laboratory of Medical Biomechanics, Southern Medical University, Guangzhou, China

Abstract OBJECTIVE While lumbar spondylolysis has been biomechanically associated with subsequent spondylolisthesis and disc degeneration, its implications on cranial adjacent segments remain unclear. This in-vitro experiment aims to quantify the segmental alterations in kinematics and contact mechanics at both L5/S1 and L4/L5 levels induced by L5 pars defects. METHODS Six fresh-frozen human lumbar cadaveric specimens (L1-S2) underwent pure moment loading (4 Nm) in flexion-extension, lateral bending, and axial rotation. Sequential testing compared intact specimens with simulated L5 bilateral spondylolysis models. Intervertebral kinematics were quantified using optical motion tracking, while L4/L5 disc contact parameters were measured using Tekscan pressure sensors. RESULTS L5/S1 segmental mobility increased in lateral bending (1.66°, p=0.002) and axial rotation (1.45°, p=0.007) in spondylolysis models. Motion increases were observed at the cranial adjacent L4/L5 segment: flexion-extension (1.89°, p<0.001), lateral bending (2.15°, p=0.002), and axial rotation (1.89°, p=0.022). However, no significant differences were detected in the L4/L5 disc contact parameters for peak contact pressure, contact area, and contact force. CONCLUSION Isthmic defects induce segmental hypermobility at the cranial adjacent segment. This kinematic alteration may accelerate disc degeneration.