ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1655686
This article is part of the Research TopicFunctional Biomaterials and Seed Cells in Tissue EngineeringView all 10 articles
An Injectable Curcumin-Loaded Hydrogel for Neuroprotective Treatment Promote Nerve Tissue Repair in Rat Severe Spinal Cord Injury
Provisionally accepted
- 1Shandong First Medical University, Jinan, China
- 2Shandong Academy of Medical Sciences (SDAMS), Jinan, China
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Spinal Cord Injury leads to severe motor and sensory impairments and underscores the urgent need for the development of effective treatment approaches. The injury microenvironment with oxidation, inflammation and extracellular matrix disruption represents a major barrier to nerve tissue repair as well as the functioning of therapeutic factors. This study proposes a curcumin-loaded boronate-crosslinked tannic acid injectable hydrogel (CBT-gel) for effective antioxidants and neuroprotective spinal cord repair. The injectable self-healing hydrogel induced sustainable release of the neuroprotective drug curcumin. The CBT-gel transplantation treatment enhanced axonal preservation and reduced glial scar formation. The results also revealed a reduction in neuroinflammation and cellular oxidative damage. These findings support the potential of CBT-gel to improve the microenvironment for spinal cord repair by leveraging their antioxidant and neuroprotective properties.
Keywords: spinal cord injury, Curcumin, Injectable hydrogel, polyphenol, Oxidative Stress
Received: 28 Jun 2025; Accepted: 13 Aug 2025.
Copyright: © 2025 Zhang, Ma, Tian, Li, Zhao, Xie and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hao Chen, Shandong Academy of Medical Sciences (SDAMS), Jinan, China
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