REVIEW article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
This article is part of the Research TopicBiodegradable Polymers for Biomedical Applications - Volume IVView all 6 articles
Mechanisms, Strategies, and Clinical Application Progress of Subcutaneous Transplantation Angiogenesis
Provisionally accepted
- 1Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, China
- 2GuangXi University of Chinese Medicine, Nanning, China
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Subcutaneous transplantation, as an important technology in cell and tissue engineering, has received considerable attention due to its simplicity of operation, strong reproducibility, and potential clinical application value. However, the limitations of the vascular network in subcutaneous tissue severely restrict the survival and functionality of transplanted cells; therefore, angiogenesis has become a key factor in improving the success rate of transplants. Currently, despite progress in the research of subcutaneous transplantation, there are still many challenges and shortcomings. This article reviews the molecular mechanisms of angiogenesis in subcutaneous transplantation, strategies involving cells and biomaterials, as well as the latest technological advancements in promoting angiogenesis. It focuses on analyzing research results in aspects such as growth factor delivery, co-transplantation of cells, scaffold material optimization, and immune regulation. At the same time, the article systematically summarizes the clinical application prospects and challenges of subcutaneous angiogenesis strategies in islet transplantation, soft tissue repair, and autoimmune diseases. By comprehensively analyzing the current research hotspots and difficulties, it aims to provide theoretical support and practical guidance for future basic research and clinical translation of angiogenesis in subcutaneous transplantation.
Keywords: Angiogenesis, co-transplantation of cells, growth factors, Immunomodulation, islettransplantation, Scaffold materials, Subcutaneous transplantation
Received: 14 Jul 2025; Accepted: 04 Nov 2025.
Copyright: © 2025 李, Ye, Chen, Guo, Xu, Jibing and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hongjun Gao, gao4056@163.com
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