REVIEW article
Front. Bioeng. Biotechnol.
Sec. Nanobiotechnology
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1671963
This article is part of the Research TopicDevelopment of novel engineered biomaterials with clinical translation prospects for chronic disease theranosticsView all articles
Clinical Applications of Extracellular Vesicles: Recent Advances and Emerging Trends
Provisionally accepted
- Naval Medical University, Shanghai, China
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Extracellular vesicles (EVs) have emerged as pivotal mediators of intercellular communication and promising theranostic agents in medicine. These naturally-derived nanoparticles possess unique advantages including stable physicochemical properties, low immunogenicity, and inherent biocompatibility. In recent years, increasing attention has been directed toward clinical investigations. Driven by these clinical studies, several EV-based diagnostic and therapeutic products have emerged. In this review, we aimed to highlight and discuss the completed and emerging clinical investigations of EV-based strategies, critically elucidate persistent technical and translational hurdles impeding clinical implementation, and propose strategic directions to accelerate realization of the transformative potential inherent in EV-mediated precision medicine.
Keywords: extracellular vesicles, clinical application, Clinical Trial, cancer theranostics, MSC-derivedEVs, Drug delivery
Received: 23 Jul 2025; Accepted: 17 Oct 2025.
Copyright: © 2025 ZOU, Zhou, Li, Dong and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yuchao Dong, dongyc1020@aliyun.com
Shi Hu, hus@smmu.edu.cn
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.