REVIEW article
Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1677422
This article is part of the Research TopicMultidimensional Study on the Development and Regeneration of Dental and Maxillofacial TissuesView all 3 articles
The application of dental mesenchymal stem cells (DMSCs) in the repair of oral and maxillofacial defects
Provisionally accepted
- 1Jinan University, Guangzhou, China
- 2Wuhan University, Wuhan, China
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Dental mesenchymal stem cells (DMSCs) are important seed cells for oral and maxillofacial tissue regeneration due to their wide availability, multi-directional differentiation potential, strong proliferation ability, maintenance of stemness after multiple proliferations, and immunomodulatory capacity. DMSCs have a wide range of sources, and different subtypes have different properties. They can promote tissue regeneration through direct differentiation into tissue cells,improvement of the local regeneration microenvironment through immunomodulatory functions, and release of various bioactive components. The article reviews the classification of DMSCs, their performance comparisons in recent years, methods of promoting tissue regeneration, and their applications in maxillofacial bone and soft tissue. Furthermore, the review explores DMSCs' excellent abilities to promote bone tissue repair when supported by various materials and repair maxillofacial soft tissue defects by promoting the regeneration of special structures of teeth such as dentin, cementum, and dental pulp vessels and nerves.
Keywords: Dental mesenchymal stem cells, dental pulp stem cells, periodontalligament stem cells, deciduous tooth pulp stem cells, gingival mesenchymal stemcells, Apical papilla stem cells, Dental follicle precursor cells, Tissue Regeneration
Received: 31 Jul 2025; Accepted: 19 Sep 2025.
Copyright: © 2025 Chen, Ma, Mai, Lai, Huang and Alimujiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Renlong Huang, hrl2024@jnu.edu.cn
Adili Alimujiang, alimujiangadili0712@jnu.edu.cn
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