ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
This article is part of the Research TopicThe Role of Platelet Derivatives in Regenerative MedicineView all 4 articles
Platelet-Rich Plasma-Enhanced "Plum Blossom" Bone Grafting for Refractory Femoral Nonunion: A Single-Center Study of 33 Cases
Provisionally accepted
- The Eighth Clinical Medical College, Foshan Hospital of Traditional Chinese Medicine, Foshan City, China
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Background: Revision surgery for femoral nonunion is technically challenging, and there is limited evidence supporting effective treatments for cases with multiple failed revisions. This study aims to evaluate the efficacy of platelet-rich plasma-enhanced "plum blossom" bone grafting combined with a bioactive chamber in treating refractory femoral nonunion after multiple failed revisions. Methods: A retrospective analysis was conducted on patients with refractory femoral nonunion treated at a high-level trauma center between January 2021 and July 2024. These patients underwent mechanical optimization, platelet-rich plasma -enhanced "plum blossom" autologous iliac bone grafting, and bioactive chamber therapy. Radiographic outcomes included union rate and limb shortening, while clinical outcomes encompassed healing time, visual analog scale pain score, SF-36 quality of life score, Harris hip score, and complications. Results: Thirty-three patients were included (24 males, 9 females), with a mean age of 42.64±13.03 years. The average number of previous surgeries was 2.64±1.17. The nonunion types were hypertrophic (4 cases, 12.10%), atrophic (24 cases, 72.70%), and oligotrophic (5 cases, 15.20%). The mean bone defect was 3.87±1.05 cm, and the mean follow-up duration was 16.06±3.37 months. The union rate was 96.97% (32/33), with a mean healing time of 9.78±1.75 months. Post-treatment, significant improvements were observed in VAS score (4.27±1.18 vs. 1.21±1.05, p<0.001), Harris hip score (50.91±8.47 vs. 86.39±7.75, p<0.001), SF-36 score (59.21±5.63 vs. 84.48±5.32, p<0.001), and limb shortening (2.20±0.64 vs. 0.32±0.57, p<0.001). Two patients (6.06%) experienced severe complications (1 case of persistent nonunion, 1 case of deep vein thrombosis). Conclusion: The synergistic effect of biomechanical stability and biological stimulation is a critical pathway to overcoming traditional treatment limitations. This study provides a reference method for managing refractory and recalcitrant femoral nonunion.
Keywords: Platelet-Rich Plasma, Nonunion, Femoral nonunion, Refractory nonunion, Recalcitrant nonunion, Diamond concept
Received: 05 Aug 2025; Accepted: 28 Nov 2025.
Copyright: © 2025 Chen, Wang, Feng, Wu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shiheng Wang
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