ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biosensors and Biomolecular Electronics
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1682103
Beyond the Time-on-Task: an EEG-driven approach for effective physiological assessment of mental fatigue in simulated and real driving
Provisionally accepted- 1Sapienza University of Rome, Rome, Italy
- 2BrainSigns, Rome, Italy
- 3ITCL, Burgos, Spain
- 4Universita degli Studi Roma Tre, Rome, Italy
- 5AIPSS, Rome, Italy
- 6EFA, Bruxelles, Belgium
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Fatigue is among the main factors contributing to road accidents. For this reason, in literature extensive effort has been invested in characterizing the fatigue state both physiologically and behaviorally. Due to safety and economic reasons, driving experiments are usually performed in simulated environments. Fatigue is typically induced through prolonged tasks, with fatigued states often defined using a Time-on-Task approach. In this study, we investigated fatigue onset in matched simulated and real driving settings, comparing the common Time-on-Task-driven approach with a novel physiology-driven approach based on EEG parameters to individually label experimental periods of Low and High Fatigue. Using a Time-on-Task approach, no difference emerged between low fatigue and high fatigue periods in the two environments. Conversely, using EEG to define high and low fatigue allowed the observation of a physiological response to fatigue onset in terms of ocular and heart activity. Results demonstrated that the approach adopted to define fatigue could impact on fatigue onset detection. The paper also provides insight into the different manifestations of fatigue in simulated and real driving.
Keywords: Mental Fatigue, Physiological assessment, EEG, Simulated driving, Real driving, Time-on-task, Heart activity, Ocular activity
Received: 08 Aug 2025; Accepted: 30 Sep 2025.
Copyright: © 2025 Giorgi, Ronca, Capotorto, Vozzi, Rossi, Aricò, Borghini, Van Gasteren, Melus, Petrelli, Sportiello, Polidori, Picardi, Babiloni and Di Flumeri. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Andrea Giorgi, andrea.giorgi@uniroma1.it
Gianluca Di Flumeri, gianluca.diflumeri@uniroma1.it
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.