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ORIGINAL RESEARCH article

Front. Bioeng. Biotechnol.

Sec. Biosensors and Biomolecular Electronics

Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1682103

Beyond the Time-on-Task: an EEG-driven approach for effective physiological assessment of mental fatigue in simulated and real driving

Provisionally accepted
Andrea  GiorgiAndrea Giorgi1*Vincenzo  RoncaVincenzo Ronca1Rossella  CapotortoRossella Capotorto1Alessia  VozziAlessia Vozzi2Dario  RossiDario Rossi1Pietro  AricòPietro Aricò1Gianluca  BorghiniGianluca Borghini1Marteyn  Van GasterenMarteyn Van Gasteren3Javier  MelusJavier Melus3Marco  PetrelliMarco Petrelli4Simone  SportielloSimone Sportiello4Carlo  PolidoriCarlo Polidori5Manuel  PicardiManuel Picardi6Fabio  BabiloniFabio Babiloni1Gianluca  Di FlumeriGianluca Di Flumeri1*
  • 1Sapienza University of Rome, Rome, Italy
  • 2BrainSigns, Rome, Italy
  • 3ITCL, Burgos, Spain
  • 4Universita degli Studi Roma Tre, Rome, Italy
  • 5AIPSS, Rome, Italy
  • 6EFA, Bruxelles, Belgium

The final, formatted version of the article will be published soon.

Fatigue is among the main factors contributing to road accidents. For this reason, in literature extensive effort has been invested in characterizing the fatigue state both physiologically and behaviorally. Due to safety and economic reasons, driving experiments are usually performed in simulated environments. Fatigue is typically induced through prolonged tasks, with fatigued states often defined using a Time-on-Task approach. In this study, we investigated fatigue onset in matched simulated and real driving settings, comparing the common Time-on-Task-driven approach with a novel physiology-driven approach based on EEG parameters to individually label experimental periods of Low and High Fatigue. Using a Time-on-Task approach, no difference emerged between low fatigue and high fatigue periods in the two environments. Conversely, using EEG to define high and low fatigue allowed the observation of a physiological response to fatigue onset in terms of ocular and heart activity. Results demonstrated that the approach adopted to define fatigue could impact on fatigue onset detection. The paper also provides insight into the different manifestations of fatigue in simulated and real driving.

Keywords: Mental Fatigue, Physiological assessment, EEG, Simulated driving, Real driving, Time-on-task, Heart activity, Ocular activity

Received: 08 Aug 2025; Accepted: 30 Sep 2025.

Copyright: © 2025 Giorgi, Ronca, Capotorto, Vozzi, Rossi, Aricò, Borghini, Van Gasteren, Melus, Petrelli, Sportiello, Polidori, Picardi, Babiloni and Di Flumeri. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Andrea Giorgi, andrea.giorgi@uniroma1.it
Gianluca Di Flumeri, gianluca.diflumeri@uniroma1.it

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