REVIEW article
Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1687840
This article is part of the Research TopicBioengineering and Biotechnology Approaches in Cardiovascular Sciences, Volume IIIView all 5 articles
Human induced pluripotent stem cell-derived cardiomyocytes for disease modeling and drug discovery
Provisionally accepted
- Fujita Medical Innovation Center Tokyo, Fujita Health University, Tokyo, Japan
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Human induced pluripotent stem cells (hiPSCs) have emerged as a promising platform for elucidating disease mechanisms and developing new drugs. Over the past two decades, it has become possible to efficiently generate large quantities of cardiomyocytes (CMs) from hiPSCs, thereby enabling the reproduction of disease-specific characteristics in culture dishes. Although this technology has the potential to substantially enhance the efficiency of drug discovery and understanding of disease, the immaturity of hiPSC-derived CMs (hiPSC-CMs) has been a major barrier to their widespread adoption. This review discusses the recent advances that address these challenges and explores the potential of hiPSCs to advance disease modeling, elucidate disease mechanisms, and accelerate drug discovery.
Keywords: Human Induced Pluripotent Stem Cells, Cardiac organoids, Engineered heart tissue, disease modeling, Drug Discovery
Received: 18 Aug 2025; Accepted: 29 Sep 2025.
Copyright: © 2025 Moriwaki, Tani and Tohyama. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shugo Tohyama, shugotohyama@keio.jp
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.