REVIEW article
Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
This article is part of the Research TopicNovel Insights into Cellular Mechanisms and Therapies for Tissue RegenerationView all 6 articles
Decoding the Exosomal Secretome: Stem Cell-Elicted Microenvironmental Reprogramming for Anterior cruciate ligament Regenerative Medicine
Provisionally accepted
- 1Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China
- 2Southwest Medical University, Luzhou, China
- 3Sichuan Academy of Medical Sciences and Sichuan People's Hospital, Chengdu, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
The ACL rupture is a prevalent and debilitating joint injury that has garnered significant clinical and scientific interest. Surgical reconstruction is often necessary for ACL rupture, yet numerous clinical cases indicate that the outcomes of such procedures are frequently suboptimal. Research has highlighted that the treatment of ACL rupture is particularly challenging due to factors such as the inflammatory response, the formation of vascular scar tissue, and the slow healing of tendon-bone interface attachment points. These complications result in poor integration of tendon grafts within bone tunnels. Recent advancements in stem cell research have introduced new possibilities for ACL rupture treatment. However, stem cell therapy is not without its limitations, including safety concerns such as the risk of aberrant differentiation leading to oncogenesis. Exosomes, a type of extracellular vesicle secreted by stem cells, have been found to modulate immune responses, promote neovascularization, influence scar formation, and regulate bone homeostasis in vivo. This review seeks to systematically evaluate the therapeutic potential of stem cell-derived exosomes in the context of ACL rupture repair.
Keywords: ACL rupture, Inflammatory Response, Stem Cell Therapy, Exosomes, neovascularization, Bone homeostasis
Received: 27 Aug 2025; Accepted: 31 Oct 2025.
Copyright: © 2025 Chen, He, Yang, He, Wei, Zhang, Zhou and Cheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Junjie Chen, 2166039875@qq.com
Ming Cheng, 17084599@qq.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.