ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biomechanics
Iso-Height Axis Correlates with Collateral Ligament Balance in Medial Compartment Knee Osteoarthritis
Provisionally accepted- 1Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
- 2Shanghai Jiao Tong University, Shanghai, China
- 3University of Pittsburgh, Pittsburgh, United States
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Purpose: A dynamic iso-height Axis (IHA) was invented based on knee flexion motion and supposed to be a target to restore knee soft tissue balance, which is critical in knee surgeries. This study aims to validate the correlation between IHA and the elongation patterns of the medial and lateral collateral ligaments (MCL and LCL). Methods: Twenty-six patients with unilateral MCKOA and intact contralateral knees were enrolled. Three-dimensional models of knee were built from CT scan. The TEA, GCA and footprints of superficial, deep MCL (sMCL, dMCL) and LCL were determined based on knee surface models. Each ligament was divided into three bundle according to the anatomical feature. Patients performed stair climbing under the surveillance of dual fluoroscopic imaging system (DFIS), and the elongation of collateral ligament bundle and IHA positions of bilateral knees were calculated. Results: Compared to the native side, the sMCL and dMCL bundles were shorter (mean -2.9 % and -6.2 %, respectively), while the LCL medial and posterior bundles were significantly longer (mean 4.5 %) in MCKOA knees. There were no significant differences in the IHA between the medial compartment knee osteoarthritis (MCKOA) knee and the native knee during daily extension. Besides, the iso-height point on the lateral femoral condyle geometrical centre axis (GCA) plane nearly overlapped with the lateral GCA point. There was a significant correlation between the differences of two-sided IHA positions and the differences of two-sided collateral ligament elongations (P<0.01). Conclusion: This study firstly validated the correlation between IHA and the elongation patterns of the MCL and LCL, suggesting that IHA can reflect longitudinal soft tissue balance state of the knee joint. This finding provides new insights for improving design and planning in future clinical interventions.
Keywords: IHA, Flexion axes, Soft tissue balance, MCKOA, Collateral ligament
Received: 30 Aug 2025; Accepted: 31 Oct 2025.
Copyright: © 2025 Jiang, Lü, Zheng, Fang, Mao, He, Xuancheng Zhang, Lin, Bao, Zheng and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: 
Zheng  Jiang, 1044526105@qq.com
Xianyou  Zheng, zhengxianyou@126.com
Wanjun  Liu, ytwanjun@sjtu.edu.cn
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
