ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biosensors and Biomolecular Electronics
This article is part of the Research TopicBiomechanical Evaluation of Bone Structural Integrity: Experimental, Computational, and Clinical PerspectivesView all articles
Quantitative Evaluation of Fracture Healing Progression in rats' femurs with Modal Damping Factor and Conventional Methods
Provisionally accepted
Stavros Chalikias1John Sarris2Stefania Athanasopoulou2
Malvina Orkoula2
Christos Kontoyannis2
VASSILIS KOSTOPOULOS2Spyridon Psarras2Nikolaos Papaioannou3Efstathios Chronopoulos4Ismene Dontas3
Sofia Panteliou2*- 1University Hospital Crosshouse, Kilmarnock, United Kingdom
- 2Panepistemio Patron, Patras, Greece
- 3Geniko Nosokomeio Attikes KAT, Athens, Greece
- 4Ethniko kai Kapodistriako Panepistemio Athenon, Athens, Greece
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Quantitative determination of bone fracture healing through objective measurements on fracture area during healing phases is of paramount importance. Simultaneous Modal Damping Factor (MDF) testing in comparison to peripheral Quantitative Computed Tomography (pQCT), Raman Spectroscopy (RS), Absorbed and Fracture Energy, was performed. MDF is a non-invasive index based on model's dynamic characteristics by applying vibration excitation. The method has already been successfully applied as structural integrity monitoring tool of defective conventional and advanced materials, including bones. We investigated whether MDF may demonstrate the proper time to have a functional and biomechanically adequately strengthened callus in osteotomized rat femurs. From the measured properties values intervals it is revealed that MDF correlates with all properties and feels with higher sensitivity the bone quality changes due to fracture and due to bone fracture healing in comparison to all other properties. The result extracted is that MDF monitors bone fracture healing and correlates with all parameters examined in a more accurate and sensitive way than any of the conventional methods. Research findings support the belief that MDF can be considered as the most convenient among the methods examined for monitoring the bone fracture healing process.
Keywords: Moda1, Damping2, Fracture3 Healing4, bone5, animal model
Received: 01 Sep 2025; Accepted: 21 Nov 2025.
Copyright: © 2025 Chalikias, Sarris, Athanasopoulou, Orkoula, Kontoyannis, KOSTOPOULOS, Psarras, Papaioannou, Chronopoulos, Dontas and Panteliou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Sofia Panteliou, sofiapanteliou@gmail.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.