ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
EXPERIMENTAL EVALUATION OF THE HEALING POTENTIAL OF SESUVIUM PORTULACASTRUM IN EXCISIONAL WOUNDS IN WISTAR RATS
Provisionally accepted
Kelly Kercy Nogueira Da Silva1Gislainy Luciana Gomes Câmara1Salvador Viana Gomes Júnior2Camila Gomes Fernandes De Souza2Kizzy Millenn De Freitas2Amália Cinthia Meneses Do Rego1
IRAMI ARAÚJO FILHO1
Roque Ribeiro Da Silva Junior2
Thales Allyrio Araújo De Medeiros Fernandes2
José Rodolfo Lopes De Paiva Cavalcanti2Fausto Pierdoná Guzen2*- 1Universidade Potiguar, Natal, Brazil
- 2University of the State of Rio Grande do Norte, Mossoro, Brazil
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This experimental study evaluated the wound-healing potential of a gel formulated with 10% macerated Sesuvium portulacastrum (Pirrixiu), a halophytic plant adapted to saline environments, in comparison with conventional treatment using Nebacetin, in Wistar rats subjected to standardized excisional wounds. The completely randomized design involved daily assessments of wound area reduction, with linear regression showing a correlation coefficient greater than 0.80 (p < 0.05), indicating a strong association between time and healing. Histological methods employed Hematoxylin and Eosin and Masson's trichrome staining to assess inflammation, collagen deposition, angiogenesis, and epithelialization. The results demonstrated that the groups treated with S. portulacastrum achieved a mean wound area reduction of up to 75% over the experimental period, with a significant increase in collagen deposition and epithelialization, comparable to the control group treated with Nebacetin (p < 0.05). Angiogenesis, assessed through vascularization, showed no significant differences between groups (p > 0.05). Inflammation analysis revealed a significant reduction compared with the positive control group (p < 0.05). No adverse effects or signs of infection or stress were observed in the animals. These findings indicate that S. portulacastrum is a promising therapeutic alternative, with sustainable potential due to its low cost and reduced environmental impact, while also promoting the appreciation of the Caatinga's biodiversity.
Keywords: Sesuvium portulacastrum, plant, wound, Treatment, Extracts, healing, Skin
Received: 17 Sep 2025; Accepted: 28 Nov 2025.
Copyright: © 2025 Da Silva, Câmara, Gomes Júnior, De Souza, De Freitas, Rego, FILHO, Ribeiro Da Silva Junior, Allyrio Araújo De Medeiros Fernandes, Cavalcanti and Guzen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fausto Pierdoná Guzen
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