Frontiers in Bioinformatics

Original Research

Published on 25 Sep 2025

Integrative machine learning and transcriptomic analysis identifies key molecular targets in MNPN-associated oral squamous cell carcinoma pathogenesis

Xiangjun Wang
Panpan Jin
Juan Xu
Junyi Li
Mengzhen Ji

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1664576

456 views

Bioinformatics

Published on 24 Sep 2025

Computational drug repurposing reveals Alectinib as a potential lead targeting Cathepsin S for therapeutic developments against cancer and chronic pain

Mohammed Alrouji
Mohammed S. Alshammari
Sharif Alhajlah
Syed Tasqeeruddin
Khuzin Dinislam
Anas Shamsi
Saleha Anwar

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1666573

438 views

Perspective

Accepted on 23 Sep 2025

The importance of democratized resources in early-career training for bioimage analysts and bioimaging scientists

Genevieve Laprade
Quinn Lee
Kristin Gallik
Michael Nelson
Natalie Woo
Celina Terán Ramírez
Alexis Ricardo Becerril Cuevas
Kevin Eliceiri
Corinne Esquibel

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1693343

119 views

Original Research

Accepted on 22 Sep 2025

Analysis of Breast Region Segmentation in Thermal Images us-ing U-Net Deep Neural Network Variants

Mohamed Hadi Habaebi
Rafhanah Shazwani
Mohammed Al Hussaini
Md Rafiqul Islam

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1609004

176 views

Original Research

Accepted on 22 Sep 2025

Inferred global dense residue transition graphs from primary structure sequences enable protein interaction prediction via directed graph convolutional neural networks

Islam Akef Ebeid
Haoteng Tang
Pengfei Gu

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1651623

369 views

Original Research

Accepted on 22 Sep 2025

Unravelling the Molecular Basis for snake venom NGF - human TrkA recognition through Molecular Dynamics Simulation and comparison with Human NGF

Shrudhi Devi
Jayaraman Gurunathan

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1674791

131 views

Brief Research Report

Published on 22 Sep 2025

Association between dysregulated expression of Ca2+ and ROS-related genes and breast cancer patient survival

Sofia Ramos
João Gregório
Ana Sofia Fernandes
Nuno Saraiva

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1633494

393 views

Original Research

Published on 22 Sep 2025

Extracting a COVID-19 signature from a multi-omic dataset

Baptiste Bauvin
Thibaud Godon
Guillaume Bachelot
Claudia Carpentier
Riikka Huusaari
Maxime Deraspe
Juho Rousu
Caroline Quach
Jacques Corbeil

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1645785

501 views

Original Research

Accepted on 19 Sep 2025

CoMPHI: A Novel Composite Machine Learning Approach Utilizing Multiple Feature Representation to Predict Hosts of Bacteriophages

Shreyashi Bodaka
Narasaiah Kolliputi

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1622931

248 views

Original Research

Accepted on 19 Sep 2025

Drug Repositioning Pipeline Integrating Community Analysis in Drug-Drug Similarity Networks and Automated ATC Community Labeling to Foster Molecular Docking Analysis

Daiana Colibășanu
Vlad Groza
Maria Antonietta Occhiuzzi
Fedora Grande
Mihai Udrescu
Lucretia Udrescu

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1666716

209 views

Original Research

Published on 19 Sep 2025

Interpretable artificial intelligence based on immunoregulation-related genes predicts prognosis and immunotherapy response in lung adenocarcinoma

Minghao Wang
Yu Wang
Yitong Li
Chengyi Zhang
Canjun Li
Nan Bi

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1613761

680 views

Original Research

Published on 19 Sep 2025

Integrated multi-optosis model for pan-cancer candidate biomarker and therapy target discovery

Emanuell Rodrigues de Souza
Higor Almeida Cordeiro Nogueira
Ronaldo da Silva Francisco Junior
Ana Beatriz Garcia
Enrique Medina-Acosta

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1630518

794 views

Original Research

Published on 19 Sep 2025

Identification and therapeutic investigation of biomarker genes underpinning hepatocellular carcinoma: an in silico study utilising molecular docking and dynamics simulation

Jishnu Ghosh
Abdullah M. Alshahrani
Aritra Palodhi
Debarghya Bhattacharyya
Subhadip Das
Sunil Kanti Mondal
Abul Kalam
S. Rehan Ahmad
Chittabrata Mal

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1567748

903 views

Original Research

Accepted on 18 Sep 2025

Discovering molecules and plants with potential activity against gastric cancer: an in silico ensemble-based modeling analysis

Micaela Villacrés
Alec Avila
Karina Jimenes-Vargas
António Machado
José M. Alvarez-Suarez
Eduardo Tejera

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1642039

342 views

Methods

Published on 18 Sep 2025

Quantitative measures to assess the quality of cellular indexing of transcriptomes and epitopes by sequencing data

Jie Sun
Robert Morrison
Soyeon Kim
Kairuo Yan
Hyun Jung Park

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1630161

1,485 views

Original Research

Published on 18 Sep 2025

BC-predict: mining of signal biomarkers and production of models for early-stage breast cancer subtyping and prognosis

Sangeetha Muthamilselvan
Natarajan Vaithilingam
Ashok Palaniappan

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1644695

640 views