CASE REPORT article
Front. Cardiovasc. Med.
Sec. General Cardiovascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1444974
Cardiovascular Syphilis: A Rare Case Report and Literature Review of Severe Aortic Regurgitation and Bilateral Coronary Ostial Stenosis.
Provisionally accepted
- Bethune First Hospital of Jilin University, Changchun, Hebei Province, China
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Due to the low incidence of cardiovascular involvement in syphilis, there are currently no established consensus or guidelines for managing such cases. The patient, with no coronary artery disease risk factors, presented with chest pain and heart failure (HF). Emergency coronary angiography revealed severe stenosis of the bilateral coronary ostia, with smooth intimal lining in the remaining coronary arteries. Echocardiography showed severe aortic regurgitation. Positive syphilis serology strongly suggested cardiovascular syphilis (CVS). The patient was transferred to cardiothoracic surgery for aortic valve replacement (AVR) and coronary artery bypass grafting (CABG), but died from acute HF despite resuscitation efforts.
Keywords: Cardiovascular syphilis, Bilateral coronary ostial stenosis, Severe aortic regurgitation, Heart Failure, differential diagnosis
Received: 19 Jun 2024; Accepted: 11 Aug 2025.
Copyright: © 2025 Wang, Zhang, Xia, Kong, Huang and Yin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: xia Yin, Bethune First Hospital of Jilin University, Changchun, Hebei Province, China
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