ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Cardiovascular Imaging
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1496853
Multi-shot gradient-echo planar imaging sequence in non-contrast coronary magnetic resonance angiography
Provisionally accepted
- 1Geriatric Hospital of Nanjing Medical University, Nanjing, China
- 2Jinling Hospital Affiliated to Nanjing university, Nanjing, China
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Objective: To explore the feasibility of multi-shot gradient-echo planar imaging (MSG-EPI) sequence in non-enhanced coronary artery magnetic resonance angiography (CMRA).: Patients undergoing CMRA in the Geriatric Hospital of Nanjing Medical University from November 2023 to May 2024 were included. We compared MSG-EPI and three-dimensional balanced turbo field echo (3D BTFE) sequence in acquisition time, subjective image score, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). With CTA as the reference standard, the linear weighted kappa and compared chi-square Mcnemar test were used to evaluate the diagnostic efficacy of both sequences for coronary artery diseases (CADs). The scale for the kappa coefficients was interpreted as follows: <0.2 = poor, 0.2-0.4 = fair, 0.4-0.6 = moderate, 0.6-0.8 = substantial, and >0.8 = excellent.Result: Seventy-two patients (33 males; mean age 54.5±14.7 years old, range from 18-79 years old) were enrolled. MSG-EPI had a significantly shorter acquisition time than 3D BTFE (17.21±1.08s vs 558.10±102.90s, P＜0.001). No significant differences in subjective scores were found between sequences for the proximal and middle segment of RCA, LM, the proximal segment of LAD and LCX (P = 0.168, 0.097, 0.126, 0.065, 0.062, respectively). SNR evaluations revealed no significant differences in the proximal and middle segment of RCA and LM segment (P = 0.119, 0.105, 0.237, respectively). However, in coronary artery segment analysis, the CNR was significantly higher in 3D BTFE compared to MSG-EPI (P all <0.05). The kappa values for MSG-EPI and 3D BTFE in assessing stenosis were 0.785 and 0.814, respectively. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of MSG-EPI were 86.7%, 83.3%, 76.5%, 90.9%, and 84.6%, respectively.The area under the curve (AUC) of MSF-EPI and 3D BTFE for CADs diagnosis was 0.850 (0.699 to 0.944) and 0.879 (0.735 to 0.961), respectively (P = 0.543).MSG-EPI sequence could significantly shorten the acquisition time and provide sufficient image quality for CADs evaluation in non-enhanced CMRA.
Keywords: Magnetic Resonance Imaging, Echo-plane imaging, image quality, diagnostic efficiency, coronary artery
Received: 09 Dec 2024; Accepted: 19 May 2025.
Copyright: © 2025 Zhu, Li, Lu, Jin, Hu, Yuan, Song and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Luo Song, Geriatric Hospital of Nanjing Medical University, Nanjing, China
Yane Zhao, Geriatric Hospital of Nanjing Medical University, Nanjing, China
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