ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1508972
Serum Albumin combine High-density lipoprotein cholesterol as a novel marker to predict Coronary Heart Disease: are their associations multiplicative or rateable?
Provisionally accepted
- Department of Emergency, Wuhan Pu'ai Hospital, Wuhan, China
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Backgroup Coronary heart disease (CHD) is a leading cause of death and disability worldwide. Albumin (ALB) and high-density lipoprotein cholesterol (HDL-c) possess potential clinical application values. However, the relationship between ALB*HDL-c (AHM) and CHD in the general population has not been studied yet. Therefore, this study aims to investigate the association between the AHM and CHD.We conducted a retrospective study using data from 2568 patients with a diagnosis of CHD from Wuhan Fourth Hospital. Patients with one or more major coronary artery or branch vessel stenosis≥50% were included in the CHD group, while patients without CHD were enrolled in the control group. Logistic regression analysis was performed to determine the influence of AHM on CHD. Receiver operating characteristic (ROC) curve was constructed to analyze the predictive value of AHM for CHD.Results A total of 1824 enrolled patients (71.0%) were diagnosed with CHD. The mean age was 64.56±10.08 years. Notably, The CHD group had a substantially lower median AHM than the control group (36.94 vs. 52.63), with a statistically significant difference (P<0.05). Specifically, Logistic regression demonstrated that AHM was an independent risk factor for CHD (OR: 0.903, 95% CI 0.888-0.918) in identifying CHD. In ROC analysis, the area under the ROC curve (AUC) for AHM [0.808 (95% CI 0.791-0.825, P<0.001)] was larger than that for ALB, HDL-c and ALB-to-HDL-c ratio (AHR), and the differences were statistically significant (P<0.05). Additionally, Gensini (GS) score was negatively correlated with AHM (R=-0.150, P<0.001). AHM was significantly associated with multi-vessel CHD (OR: 0.903, 95%CI 0.888-0.918) and ROC analysis showed an AUC of 0.639 for AHM in predicting multi-vessel CHD.Conclusion AHM was significantly linked to an elevated risk of CHD. The lower the AHM level, the greater the CHD occurrence rate. AHM is not only associated with the occurrence of CHD, but also to the severity of coronary artery stenosis. This underscores the crucial value of AHM in the discrimination and management of CHD.Keywords Albumin, High-density lipoprotein cholesterol, Coronary heart disease, Albumin multiply by high-density lipoprotein cholesterol (AHM). Albumin high-density lipoprotein cholesterol ratio (AHR)
Keywords: albumin, High-density lipoprotein cholesterol, coronary heart disease, Albumin multiply by high-density lipoprotein cholesterol, Albumin high-density lipoprotein cholesterol ratiolesterol ratio
Received: 05 Nov 2024; Accepted: 08 Jul 2025.
Copyright: © 2025 He, Chen, Zhu and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Li He, Department of Emergency, Wuhan Pu'ai Hospital, Wuhan, China
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