REVIEW article
Front. Cardiovasc. Med.
Sec. Cardiovascular Pharmacology and Drug Discovery
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1514911
Medicinal Plants Administered to Control Hypertension in Ethiopia: Ethnomedicine, Pharmacology, Nutraceutical, Phytochemistry, and Toxicology, Policy Perspectives
Provisionally accepted
- 1College of Medicine and Health Sciences, Mizan-Tepi University, Mizan-Aman, Ethiopia
- 2Debre Markos University, Debre Marqos, Ethiopia
- 3Department of Pharmacy, College of Health Sciences, Mettu university, Mettu, Ethiopia
- 4School of Pharmacy, Faculty of Health Sciences, Institute of Health, Jimma University, Jimma, Oromia Region, Ethiopia
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In traditional folk medicine, medicinal plants are widely employed. High blood pressure, a major cause of morbidity and mortality in healthcare settings, is linked to the risk of cardiovascular illnesses and many other serious health issues that can develop from it. This review provides background regarding hypertension, including introductory concepts, risk factors, and treatment approaches. Hypertension may not be effectively treated with the use of diuretics, ACE inhibitors, beta-blockers, alpha-blockers, calcium channel blockers, direct vasodilators, renin inhibitors, etc. These drugs' side effects include intolerance, weakened disease control, and improper therapy management. Therefore, an approach for extracting new therapeutic chemicals from medicinal plants is receiving attention today. As a result, this article provides a list of 85 plant species from 40 families, compiling data on ethnobotanical claims, plant parts used to make extracts, different types of extracts and study animals, nutracuticals' intended use, the antihypertensive effect of the extracts, their mode of action, clinical trials, toxicity profile, etc. It also mentions 55 specific chemical compounds that have shown potential to lower blood pressure in lab tests and live subjects, along with their dosage and how they work, based on online searches of published studies from different sources. Researchers looking into and developing new anti-hypertensive therapies to treat hypertension would benefit from our current work. We also tried to address the policy implications.
Keywords: Hypertension,, pathogensis,, Anti-hypertensive, medicinal plants, nutraceuticals,, phytochemicals, policy, Ethiopia
Received: 21 Oct 2024; Accepted: 10 Jul 2025.
Copyright: © 2025 Nureye, Tadege, DINSSA, Kebebe Borga and Suleman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dejen Nureye, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan-Aman, Ethiopia
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.