ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Lipids in Cardiovascular Disease
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1524847
This article is part of the Research TopicCardiovascular calcification: disease mechanisms, clinical phenotypes and therapeutic strategiesView all 3 articles
Lipid Accumulation Product Index is Inversely U-shaped Associated with Abdominal Aortic Calcification Based on NHANES 2013-2014
Provisionally accepted
Jiangbei Deng1,2
Xiao Qin1*- 1Department of Vascular Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
- 2Department of Peripheral Vascular Intervention, Changsha Central Hospital, University of South China, Changsha, China
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Background: In this study, we explored the correlation between lipid accumulation product (LAP) and abdominal aortic calcification (AAC).Methods: Data collected from 2013 to 2014 were obtained from the National Health and Nutrition Examination Survey (NHANES) database. We utilized weighted univariate and multivariate regression analyses to assess the correlation between ln-LAP (LAP was transformed using a natural logarithm) and AAC. Further, subgroup analyses, smoothed curve fitting, and sensitivity analysis were implemented.Results: The study included 2965 participants, with a mean ln-LAP index of 3.95 ± 0.83. Following adjustment for all covariates, multiple regression analyses indicated that ln-LAP, when modeled as a quadratic categorical variable, was significantly positively associated with AAC in Q3 (OR= 1.91; 95%CI: 1.20, 3.04, P <0.001) compared to the Q1, and similarly, with severe abdominal aortic calcification (SAAC) in Q4 (OR= 2.17; 95%CI: 1.08, 4.35, P <0.05). Conversely, Q2, Q3, and Q4 did not exhibit significant positive correlations with AAC scores (P >0.05). Smoothed curve fitting revealed a nonlinear relationship between ln-LAP and AAC, characterized by an inverse U-shaped curve. Threshold effect analysis identified an inflection point at 4.21. Before this point, a marked positive correlation existed between ln-LAP and AAC (OR= 1.74); beyond this point, a pronounced negative correlation was observed (OR= 0.60). Subgroup analyses revealed no significant interactions regarding the correlation across age, sex, hypertension, and diabetes groups (P interaction >0.05).Conclusions: This research reveals a significant inverse U-shaped correlation between LAP and the prevalence of AAC, implying that LAP could serve as a potential biomarker for evaluating AAC risk.
Keywords: Lipid accumulation product, ABDOMINAL AORTIC CALCIFICATION, Visceral obesity index, NHANES, Cross-sectional study Words number: 2771, figures number: 2, tables number: 4
Received: 08 Nov 2024; Accepted: 26 May 2025.
Copyright: © 2025 Deng and Qin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiao Qin, Department of Vascular Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
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