ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Cardiovascular Epidemiology and Prevention
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1528540
This article is part of the Research TopicAdvancing Vascular Health: A Comprehensive Framework for Non-Traditional Risk AssessmentView all 3 articles
Association of Plasma Homocysteine With Cardiovascular Disease in American Adults: A Study Based on the National Health and Nutrition Examination Survey Database
Provisionally accepted
- 1Xiamen University, Xiamen, China
- 2Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China
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The purpose of this study was to investigate the correlation between plasma homocysteine (Hcy) levels and cardiovascular disease (CVD) in United States adults based on the National Health and Examination Survey (NHANES) database of the United States.Methods: Data from two survey periods (2003 to 2006) in the NHANES database were used as the research data set. Plasma Hcy levels are considered an independent variable, while CVD is a dependent variable. Weighted logistic regression, linear trend analysis, subgroup analysis and limiting cubic spline plots were used for analysis. A total of 4,418 samples were included.In the weighted logistic regression model, a significant positive correlation between Hcy level and CVD risk was observed (P for trend=0.007).The subgroup analysis revealed that various characteristics such as age, race, education level, obesity, alcohol use, diabetes, and hypertension did not affect this positive correlation (P for interaction ≥0.05). The nonlinear association between Hcy level and CVD risk was explored by limiting cubic spline plots, revealing the overall significant trend (P for overall <0.0001) and the significant nonlinear trend (P for nonlinear <0.01).In this large cross-sectional study, an increase in Hcy levels leads to an increased risk of CVD. There is a nonlinearly positive correlation between Hcy levels and the risk of CVD.
Keywords: cardiovascular disease, Homocysteine, Logistic regression, Linear trend analysis, National Health and Examination Survey
Received: 15 Nov 2024; Accepted: 28 May 2025.
Copyright: © 2025 Huang, Zhang, Zhang, Zhang, Huang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Demin Xu, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China
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