ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Heart Failure and Transplantation
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1530271
This article is part of the Research TopicOutcome-Oriented Approaches to Arrhythmia and Heart Failure TreatmentView all 13 articles
The l evel of human epidi dymis protein 4 i s associ ated with poor prognosis i n patients with ej ecti on fracti on preserved heart failure
Provisionally accepted
- Hunan Provincial People's Hospital, Changsha, China
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I ntroduction: The prognosti c value of human epidi dymis protein 4 (HE4) i n patients with heart failure with preserved ej ecti on fracti on (HFpEF) i s unknown. Methods: Patients diagnosed with HFpEF i n the Department of Cardi ovascular Medi ci ne of Hunan Provinci al People' s Hospital from January 2021 to August 2022 were prospectively enrol led i n the study. Serum l evels of HE4 were measured using a chemi lumi nescence mi croparticle i mmunoassay. Endpoint events i ncluded readmi ssi on for heart failure and cardi ovascular death. Results: A total of 170 patients with HFpEF were i ncluded i n the study; among them, 86 (50. 6%) were male, with a mean age of 68.9 ± 0. 8 years. A total of 71 patients experienced endpoint events, i ncludi ng 67 patients with rehospitali zati ons for heart failure and 4 patients with cardi ovascular deaths, with an average fol low-up of 18.0 ± 0. 8 months. Multivari ate Cox regressi on analysis revealed that HE4 was an i ndependent predictor of endpoi nt events (HR = 1.009, 95% CI 1.002-1.015, P = 0.010). The Kapl an-Meier survi val curves revealed that the ri sk of endpoi nt events was si gnifi cantly higher i n patients with HE4 > 42.45 pmol/L than i n those with HE4 ≤ 42.45 pmol/L (HR = 2. 66, 95% CI 1. 37-5. 17, P < 0. 01). After adjusting for age and gender, the HR was 2. 48 (95% CI 1. 21-5. 08, P < 0. 05). Conclusion: HE4 i s an i ndependent predictor of heart failure rehospitalizati on and cardi ovascular death i n patients with HFpEF.
Keywords: Ej ecti on fraction preserved heart failure, Human epidi dymis protein 4, prognosis, Bi omarker, Fi brosi s
Received: 18 Nov 2024; Accepted: 02 Jul 2025.
Copyright: © 2025 Tang, Chen, Huang, Hu, Hu, Peng and Pan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yongjun Hu, Hunan Provincial People's Hospital, Changsha, China
Si-Ling Peng, Hunan Provincial People's Hospital, Changsha, China
Hong-Wei Pan, Hunan Provincial People's Hospital, Changsha, China
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