ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Atherosclerosis and Vascular Medicine
Analysis of the clinical value of combined monitoring of methylation transferase Wilms' tumour 1-associating protein and Lipoprotein-associated phospholipase A2 in patients with coronary artery disease
Provisionally accepted
- 1Department of Clinical Laboratory, Henan Provincial People’ Hospital; People’ Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
- 2Department of Clinical Laboratory, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
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OBJECTIVE: Clinical significance and correlation study of methyltransferase Wilms' tumour 1associated protein (WTAP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) in patients with coronary artery disease(CAD). METHODS: This study enrolled 282 symptomatic patients with suspected CAD. Serum biomarkers including lipids, inflammatory markers (CRP, Lp-PLA2), and WTAP mRNA levels (quantified via RT-PCR) were analyzed. Coronary severity was assessed using Gensini scores. RESULTS: CAD patients exhibited significantly elevated WTAP expression and higher Lp-PLA2 levels. WTAP correlated strongly with Lp-PLA2, CRP, and Gensini scores. Multivariate analysis identified WTAP and Lp-PLA2 as independent CAD predictors. Combined WTAP/Lp-PLA2 detection demonstrated superior diagnostic performance (AUC=0.9548, sensitivity=95.26%, specificity=90.16%).CONCLUSION: WTAP and Lp-PLA2 synergistically reflect CAD progression , offering dual biomarkers for risk stratification.
Keywords: Coronary Artery Disease, WTAP, Lp-PLA2, Inflammatory markers, methylation transferase
Received: 05 Dec 2024; Accepted: 20 Nov 2025.
Copyright: © 2025 Guo, Hu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Gang Li, 865932892@qq.com
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