ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1544125
This article is part of the Research TopicFighting Against Coronary and Peripheral Calcification During Percutaneous InterventionsView all articles
A positive linear correlation between the triglyceride-glucose index and in-stent restenosis after percutaneous coronary intervention in patients with coronary heart disease
Provisionally accepted
- Department of Emergency Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
The association between the triglyceride-glucose (TyG) index and in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD) remains inadequately explored. This study aimed to evaluate the relationship between TyG and ISR in patients with CHD following PCI.Methods: This retrospective study included 519 patients with CHD undergoing PCI. TyG, considered as the exposure variable, was divided into lower (≤ 9.21) and higher (> 9.21) groups based on the optimal cutoff determined by receiver operator characteristic (ROC) analysis, with ISR as the outcome variable. Multivariable logistic regression, subgroup analysis, ROC analysis and restricted cubic spline (RCS) modeling were used to assess the association between TyG and ISR.Results: Patients with higher TyG had a significantly greater incidence of ISR compared to patients with lower TyG (P = 0.003). Patients with ISR had higher levels of TyG compared with patients without ISR (P = 0.006). In multivariable logistic regression analysis, after adjusting for confounding variables, a higher TyG index was significantly associated with an increased risk of ISR, both as a categorical and a continuous variable [Model 3, OR (95% CI), P value: 1.786 (1.134, 2.814), 0.012 and 1.408 (1.034, 1.917), 0.030, respectively]. The association remained significant in subgroups aged < 60 years, male, non-smokers, and those with hypertension (P < 0.05). Additionally, ROC analysis showed that TyG had modest predictive value for ISR (AUC = 0.571, P = 0.020), and its addition to the baseline model significantly improved the overall predictive performance (AUC = 0.643, P < 0.001).RCS analysis further confirmed a positive linear correlation between TyG and ISR (P = 0.042; P for nonlinearity = 0.808).A higher TyG index is significantly associated with an increased risk of ISR in CHD after
Keywords: Triglyceride-glucose index, In-stent Restenosis, coronary heart disease, Percutaneous Coronary Intervention, biomarker
Received: 12 Dec 2024; Accepted: 14 Jul 2025.
Copyright: © 2025 Mao, Fang, Jiang and Xia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zeyan Xia, Department of Emergency Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.