ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Cardiovascular Epidemiology and Prevention
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1544273
Trends in the global burden of aortic valve calcification disease in the working-age population from 1992 to 2021
Provisionally accepted
- 1Tianjin Medical University General Hospital, Tianjin, China
- 2Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China
- 3Northern Theater Command General Hospital, Shenyang, Liaoning Province, China
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Background: Calcific aortic valve disease (CAVD) is a degenerative condition marked by aortic valve thickening and calcification, leading to stenosis or regurgitation, with rising prevalence in developed countries.Objectives: This study aimed to analyze the epidemiological trends and disease burden of CAVD in the global working-age population (defined in this study as the age group of 15 to 64 years) from 1992 to 2021. It further examined differences by Sociodemographic Index (SDI) regions and gender, providing insights for public health strategies.Methods: Data were obtained from the Global Burden of Disease (GBD) 2021 study, using agestandardized rates (ASR) to adjust for differences in age distribution across populations, allowing for more accurate comparisons of disease burden over time and between regions. Trends were analyzed using Joinpoint regression, and health disparities were assessed using Slope and Concentration
Keywords: Global burden of disease, Calcific aortic valve disease, sociodemographic index, Prevalence, Incidence
Received: 12 Dec 2024; Accepted: 07 May 2025.
Copyright: © 2025 Wu, Yang, Li, Wei, Sun, Xia, Zhu and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Songzhe Wu, Tianjin Medical University General Hospital, Tianjin, 300052, China
Yan Zhu, Northern Theater Command General Hospital, Shenyang, 110017, Liaoning Province, China
Naishi Wu, Tianjin Medical University General Hospital, Tianjin, 300052, China
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