ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Heart Failure and Transplantation
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1547755
This article is part of the Research TopicAddressing insulin resistance and hyperinsulinemia for cardiovascular disease preventionView all 11 articles
Association Between Triglyceride-Glucose Index and 6-Month Readmission In Patients With Heart Failure: A Cohort Study
Provisionally accepted
- 1Panyu Maternal And Child Care Service Centre Of Guangzhou, Guangzhou, China
- 2Guangzhou Panyu district maternal and child care family planning service center, Guangzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Insulin resistance (IR) significantly impacts outcomes in heart failure (HF) patients, by the triglyceride-glucose (TyG) index serving as an effective marker of metabolic dysfunction. However, its association with HF readmission risk is still uncertain.Methods: This study analyzed 901 HF patients using multivariable logistic regression and restricted cubic splines to evaluate the relationship between the TyG index and 6-month readmission risk.Results: Patients in the lowest TyG quartile (Q1) had a significantly higher risk of 6-month readmission across models: Model 1 (odds ratio [OR] 1.72, 95% confidence interval [CI] 1.16-2.53; p = 0.007), Model 2 (OR 1.83, 95% CI 1.23-2.72; p = 0.003), and Model 3 (OR 1.71, 95% CI 1.12-2.61; p = 0.012). A nonlinear relationship between the TyG index and the 6month readmission risk was observed (p for nonlinearity = 0.046).Furthermore, significant interactions were detected between the TyG index and body mass index (BMI) subgroups (p for interaction = 0.002).Including the TyG index modestly improved predictive performance, particularly in abnormal BMI patients.A nonlinear relationship between the TyG index and 6-month readmission risk in HF patients. Subgroup analyses revealed that a lower TyG index was significantly connected to a higher readmission risk, especially in patients with abnormal BMI. Although the TyG index 3 / 30 improved predictive performance, its overall discriminative ability remained modest, demonstrating greater utility in populations with abnormal BMI.
Keywords: Triglyceride-glucose index, Heart Failure, Insulin Resistance, BMI, cohort study
Received: 15 Jan 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 Li, Jiang, Zheng, Lin, Feng, Zhuo and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Peng Zhang, Panyu Maternal And Child Care Service Centre Of Guangzhou, Guangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.