SYSTEMATIC REVIEW article
Front. Cardiovasc. Med.
Sec. Hypertension
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1550435
Effects of different exercise modalities on blood pressure and endothelial function in prehypertension individuals: a systematic review and network meta-analysis
Provisionally accepted
Yingtian Yang1
Qianyu Lv1
Hou Xin-zheng1
Yanfei Lv2Xirui Zhang3
Qian Wu1
Xuejiao Ye1
Chenyan Yang1Mingyu Huang1
Shihan Wang1*- 1Department of Cardiovascular Internal Medicine, Guang’anmen Hospital, Beijing, China
- 2Fudan University, Shanghai, Shanghai Municipality, China
- 3Inner Mongolia Baogang Hospital, Baotou, China
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Objective: To evaluate the relative impacts of various exercise protocols on blood pressure (BP) and endothelial function in prehypertension individuals.Methods: In this systematic review and network meta-analysis (NMA), PubMed, Cochrane Library, Web of Science, Embase, CINAHL, SPORTDiscus, and Rehabilitation & Sports Medicine databases were searched until September 12, 2024. Randomized controlled trials that examined the effectiveness of exercise treatments on people with prehypertension compared to a non-exercise control group or other exercise modes were included. A Bayesian NMA were applied to examine SBP, DBP, flow-mediated dilation (FMD), and pulse wave velocity (PWV). The surface underneath the cumulative ranking curve data was utilized to rate interventions. Confidence was evaluated using the CINeMA framework.Results: A total of 18 articles with 2,592 individuals were included in the NMA. Tai Chi demonstrated the greatest decrease in SBP of -8.67 mm Hg (95% credible interval (CI): -17.29 to -0.05), while isometric exercise training (IET) exhibited the most substantial enhancement in DBP of -4.61 mm Hg (95% CI: -8.11 to -1.11) and PWV of -0.82 m/s (95% CI: -1.58 to -0.06). Moderate-intensity continuous training yielded the largest improvement in FMD at 5.82% (95% CI: 5.41 to 6.22).Conclusion: Diverse exercise modalities can enhance BP and vascular function in prehypertensive patients. Overall, Tai Chi and IET are the most productive exercises for reducing BP, with IET being particularly effective in diminishing arterial stiffness. MICT stands out in enhancing endothelial function. Nevertheless, further comprehensive studies encompassing more diverse exercise treatments are necessary to ascertain the best exercise patterns and dosing strategies.Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=614765, identifier: CRD42024614765.
Keywords: Exercise, Prehypertension, Blood Pressure, Endothelial Function, Network meta-analysis
Received: 27 Jan 2025; Accepted: 06 Jun 2025.
Copyright: © 2025 Yang, Lv, Xin-zheng, Lv, Zhang, Wu, Ye, Yang, Huang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shihan Wang, Department of Cardiovascular Internal Medicine, Guang’anmen Hospital, Beijing, China
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