ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Lipids in Cardiovascular Disease
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1551203
Non-High-Density Lipoprotein Cholesterol Predicts Cardiovascular Risk Better than Remnant Cholesterol in Patients with Type 2 Diabetes Mellitus The Predictive Value of Non-HDL and Remnant Cholesterol in Cardiovascular Disease Risk among T2DM Patients
Provisionally accepted
- University of Cape Coast, Cape Coast, Ghana
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Background: Cardiovascular disease (CVD) is a leading cause of morbidity in patients with type 2 diabetes mellitus (T2DM). Non–high-density lipoprotein cholesterol (non-HDL-C) and remnant cholesterol (RC) have emerged as promising markers of atherogenic risk, but their comparative predictive performance remains uncertain, particularly in resource-limited settings.Objective: This study evaluated the predictive value of non-HDL-C and RC for atherosclerotic cardiovascular disease (ASCVD) risk and associated inflammatory and metabolic disturbances in T2DM patients.Methods: A cross-sectional study was conducted among 154 T2DM patients attending the outpatient diabetic clinic at the Effia Nkwanta Regional Hospital, Ghana. Non-HDL-C and RC were calculated from fasting lipid profiles. The TyG index was used as a surrogate for insulin resistance. ASCVD risk was assessed using the Framingham risk score. Logistic regression and ROC analysis were performed to assess predictive utility. Subgroup analyses were conducted based on BMI, hypertension, and TyG index.Results: Non-HDL-C was significantly associated with higher ASCVD risk and elevated hs-CRP and resistin levels, while RC showed weaker, non-significant associations. Non-HDL-C had a higher AUC (0.78 vs. 0.62), sensitivity, and specificity. Nearly half of participants (49.4%) had elevated TyG index (>8.7). Non-HDL-C consistently outperformed RC across subgroups.Conclusion: Non-HDL-C is a stronger and more practical predictor of ASCVD risk than RC in T2DM patients, particularly in settings with limited access to advanced lipid testing. Its use alongside the TyG index offers a cost-effective approach for enhancing cardiovascular risk stratification in diabetes care.
Keywords: type 2 diabetes mellitus, Remnant cholesterol, Non-HDL cholesterol, metabolic syndrome markers, diabetes, lipidology, nutrition, and metabolic diseases, TyG index
Received: 03 Mar 2025; Accepted: 02 Jun 2025.
Copyright: © 2025 Nsiah, Acquah, Bockarie, Adjei, Aniakwaa- Bonsu and Ryabinina. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Paul Nsiah, University of Cape Coast, Cape Coast, Ghana
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