ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. General Cardiovascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1555557
Clinical Outcomes in Recently Diagnosed Atrial Fibrillation Related to Mitral Stenosis Compared to Non-Valvular Atrial Fibrillation
Provisionally accepted
Mohamed Aboelhassan1*
Hosam Hasan-Ali1
Mohammed Taha Mohammed1
Amr Ashry2Mohamed Aboel-Kassem F. Abdelmegid1- 1Department of Cardiology, Faculty of Medicine, Assiut University, Assiut, Egypt
- 2Department of Cardiothoracic Surgery, Faculty of Medicine, Assiut University, Assiut, Egypt
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Background: Atrial fibrillation (AF) is the most common sustained arrhythmia in adults and is associated with significant morbidity and mortality. Mitral stenosis (MS) is common in developing countries, affecting the younger population and posing a risk of atrial fibrillation.Objectives: The aim of this study is to delineate the clinical characteristics and poor outcomes in patients who have recent non-valvular AF (NVAF) compared to AF related to MS (MS-AF). Furthermore, it seeks to assess the healthcare resource utilization associated with the management of AF patients in the two groups.Patients and methods: This is a prospective observational cohort conducted on 84 patients with recent AF. The patients were divided into two groups; the NVAF group (patients with no prosthetic valves or moderate/severe MS) and the MS-AF groups (patients with AF in the presence of moderate/severe MS). The clinical characteristics, stroke risk, and anticoagulation regimens were assessed. AF-related outcomes (strokes, hospitalizations, major bleeding and mortalities) were monitored and compared between the two groups. Results: The mean age of the studied AF patients was 49.80 ± 16.31 years, ranging from 25 to 89 years. Patients with MS-AF were significantly younger than patients with NVAF. Hypertension was the most prevalent risk factor associated with AF. Smoking, heart failure, & hypertension were more prevalent among patients with NVAF. The NVAF group received less anticoagulants than the MS-AF group. There were no statistically significant differences between the two groups regarding the overall incidence of death, stroke, myocardial infarction, TIA, or hospital admissions. In the overall studied group, all-cause mortality was higher among AF patients with history of heart failure or stroke. Conclusion: Patients with NVAF had a significantly greater incidence of cardiovascular disease risk factors. However, AF related to mitral stenosis was associated with comparable worse outcomes.
Keywords: Mitral stenosis, Atrial Fibrillation, Non-valvular atrial fibrillation, NVAF, Rheumatic Heart Disease
Received: 04 Jan 2025; Accepted: 27 May 2025.
Copyright: © 2025 Aboelhassan, Hasan-Ali, Mohammed, Ashry and F. Abdelmegid. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mohamed Aboelhassan, Department of Cardiology, Faculty of Medicine, Assiut University, Assiut, Egypt
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