CASE REPORT article
Front. Cardiovasc. Med.
Sec. Structural Interventional Cardiology
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1555718
This article is part of the Research TopicCase Reports in Structural Interventional Cardiology: 2024View all 7 articles
Patient-Specific Three-Dimensional Printing and Computational Fluid Dynamics in the Planning of Transcatheter Aortic Valve Replacement for Quadricuspid Aortic Valve Author Names
Provisionally accepted
- 1Department of Cardiovascular Surgery, General Hospital of Ningxia Medical University, Yinchuan, Henan Province, China
- 2Graduate School of Ningxia Medical University, Yinchuan, Ningxia Hui Region, China
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Background: Performing transcatheter aortic valve replacement (TAVR) in patients with high-risk quadricuspid aortic valve (QAV) may be feasible, but uncertainties remain regarding the development of a comprehensive procedural plan and predicting the outcomes. Case summary: We report a case of a 70-year-old patient with a high-risk (EuroSCORE II: 11.2 %) QAV (type B) and severe aortic regurgitation (regurgitant jet area measuring 9.8 cm²). To avoid high-risk surgery, we selected a 29-mm J-Valve for the transapical TAVR without the occurrence of paravalvular leak based on a patient-specific 3D printed model. Computational fluid dynamics simulations were performed to evaluate the hemodynamic parameters pre- and post-TAVR and showed that the trans-aortic valve pressure gradient decreased from 4.7 mmHg to 3.5 mmHg, the peak trans-aortic velocity decreased from 1.02 m/s to 0.89 m/s, and the low wall shear stress area was increased from 18.92 cm2 to 19.15 cm2. These findings suggest the effectiveness of the TAVR procedure. Based on the simulation results, the procedure was successfully implemented, leading to an improvement in the patient's clinical status. Conclusion: Three-dimensional printing and computational fluid dynamics simulations may be valuable tools for planning, assessing procedural outcomes, and evaluating risks in TAVR procedures for patients with QAV.
Keywords: Transcatheter aortic valve replacement, Quadricuspid aortic valve, Aortic regurgitation, computational fluid dynamics, three-dimensional printing 1. Introduction
Received: 05 Jan 2025; Accepted: 24 Jun 2025.
Copyright: © 2025 Zhang, Cai, Wang, Du, Gu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaodong Li, Department of Cardiovascular Surgery, General Hospital of Ningxia Medical University, Yinchuan, Henan Province, China
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