SYSTEMATIC REVIEW article
Front. Cardiovasc. Med.
Sec. Heart Failure and Transplantation
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1556606
Investigating the effect of SGLT2 inhibitors on cardiovascular related health status in HFmrEF and HFpEF: Systematic Review and Meta Analysis
Provisionally accepted
Tabitha Kusi-Yeboah1*
Isaac Gianfrancesco1
Muzammil Arif Din Abdul Jabbar1
Phoebe Collins1
Dalton James Bally2
Juliet Thornton1
Kieran Williams2
Ayoola Ishola1Lucy Hong1
Ping Jing Toong1Milindu Wickramarachchi1- 1University of Cambridge, Cambridge, United Kingdom
- 2University College London, London, England, United Kingdom
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Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have emerged as an integral component of heart failure management, with evidence supporting their benefits across a broad spectrum of ejection fractions. However, their impact on quality of life (QoL) in patients with heart failure with mildly reduced (HFmrEF) and preserved ejection fraction (HFpEF) remains underexplored. This systematic review and meta-analysis aim to evaluate the effects of SGLT2i on QoL compared to standard therapy in these patient populations.A systematic search of PubMed, Cochrane, and EMBASE databases was conducted for randomized controlled trials (RCTs) published in English that assessed the clinical outcomes of SGLT2i in HFpEF and HFmrEF up to January 23, 2024. Two independent reviewers evaluated the risk of bias for eligible studies. A random-effects model was used for meta-analysis. The primary outcomes of interest were changes in the Kansas City Cardiomyopathy Questionnaire (KCCQ) score and 6-Minute Walk Test Distance
Keywords: SGLT2 inhibitors (SGLT2i), Heart Failure, HFmrEF, HFPEF, Quality of Life, Cardiovascular health, Systematic review, Meta-analysis
Received: 07 Jan 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Kusi-Yeboah, Gianfrancesco, Jabbar, Collins, Bally, Thornton, Williams, Ishola, Hong, Toong and Wickramarachchi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tabitha Kusi-Yeboah, University of Cambridge, Cambridge, United Kingdom
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