Non-Linear Association Between the Dietary Index for Gut Microbiota and the Atherogenic Index of Plasma: Insights from a Cross-Sectional Study

Liu Tian-Ding¹Zheng Yangyang^2,3Jinying Zhang^1*

• ¹Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
• ²Department of General Surgery, Beijing Hospital, Beijing, China
• ³China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China

The gut microbiota plays a crucial role in the development of atherosclerosis. The Dietary Index for Gut Microbiota (DI-GM) assesses the impact of diet on gut microbiota, and the Atherogenic Index of Plasma (AIP) serves as a key marker for evaluating atherosclerosis. However, studies exploring the association between DI-GM and AIP remain limited.Data from the 2007-2020 National Health and Nutrition Examination Survey (NHANES) were analyzed, including 15,471 participants. Weighted multivariate linear regression models were employed to evaluate the linear association between DI-GM and AIP, while restricted cubic splines (RCS) were used to assess potential nonlinear relationships.After adjusting for confounding factors, multivariate linear regression analysis demonstrated a significant negative correlation between DI-GM levels and AIP. Each one-point increase in DI-GM was associated with a 0.007-point reduction in AIP (95% CI: -0.012 to -0.002). Categorical analysis further revealed that participants in the DI-GM ≥6 group had significantly lower AIP levels compared to those in lower DI-GM groups (β = -0.038, 95% CI: -0.059 to -0.017; P for trend = 0.007). Restricted cubic spline (RCS) analysis identified a significant non-linear dose-response relationship (P for non-linearity = 0.018) with a threshold at DI-GM = 3.467. Below this threshold, the association was nonsignificant; however, above it, each unit increase in DI-GM corresponded to a 0.011 decrease in AIP (P < 0.001). Subgroup analyses indicated that the relationship between DI-GM and AIP was significantly moderated by age, race/ethnicity, hypertension, and diabetes (P for interaction < 0.05).This study demonstrated a non-linear dose-response relationship between DI-GM levels and AIP, with a significant threshold effect at DI-GM = 3.467. Beyond this threshold, higher DI-GM levels were linked to lower AIP, moderated by age, race/ethnicity, hypertension, and diabetes.