REVIEW article

Front. Cardiovasc. Med.

Sec. Cardiovascular Genetics and Systems Medicine

Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1559064

This article is part of the Research TopicDecoding Epigenetics in Vascular Health: From Basic Science to TherapeuticsView all 3 articles

Emerging Mechanisms and lmplications of m6A in CVDs: Potential Applications of Natural Products

Provisionally accepted
Hui WangHui Wang1Yun ZhangYun Zhang2Xiao JiangXiao Jiang1Guichun LiuGuichun Liu1Shujuan XuShujuan Xu1Jinbiao HeJinbiao He3Xudong HeXudong He2Ting XiaoTing Xiao1Lijuan WangLijuan Wang1LiJing XiaoLiJing Xiao1Xinhui LiXinhui Li1*
  • 1Hunan University of Chinese Medicine, Changsha, China
  • 2Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China
  • 3Yunnan Characteristic Plant Extraction Laboratory, School of Chemical Science and Technology, Yunnan University, Kunming, China

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N6-methyladenosine (m6A) RNA methylation is the most common, abundant, and reversible epigenetic modification of RNAs, and it directs many essential processes in RNAs post-transcriptionally. It has been shown that m6A modification affects cardiovascular diseases (CVDs) by regulating RNA splicing, localization, translation, and stabilization and regulating processes such as autophagy, apoptosis, inflammatory responses, and oxidative stress. A growing body of evidence has shown that natural products have the unique advantage of being highly effective with few side effects and have significant effects against CVDs. However, few studies have explored the relationship between natural products and m6A modification in the development of CVDs. In this review, we summarized the biological functions of m6A modification and discussed the potential mechanisms and processes of m6A modification in various CVDs; we also summarized the research progress of natural products modulating m6A modification in the treatment of CVDs. This review further elucidated the relationship between the modification of m6A methylation and CVDs, thereby contributing to the development of potential therapeutic agents from natural products.

Keywords: m6A methylation, Cardiovascular Diseases, Natural Products, Biological Processes, epigenetic modification

Received: 11 Jan 2025; Accepted: 15 Jun 2025.

Copyright: © 2025 Wang, Zhang, Jiang, Liu, Xu, He, He, Xiao, Wang, Xiao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Xinhui Li, Hunan University of Chinese Medicine, Changsha, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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