ORIGINAL RESEARCH article

Front. Cardiovasc. Med.

Sec. Cardiovascular Imaging

Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1572318

High-resolution 3D whole-heart bright-and black-blood imaging with co-registered T2 mapping at 0.55T

Provisionally accepted
Ivan KokhanovskyiIvan Kokhanovskyi1,2,3Carlos Castillo-PassiCarlos Castillo-Passi3,4Michael G. CrabbMichael G. Crabb3Carl GanterCarl Ganter1Simon J. LittlewoodSimon J. Littlewood3Karl P. KunzeKarl P. Kunze3Dimitrios C. KarampinosDimitrios C. Karampinos1Marcus R MakowskiMarcus R Makowski1Daniel RueckertDaniel Rueckert5,6Claudia PrietoClaudia Prieto3,4René M. BotnarRené M. Botnar2,3,4*
  • 1Institute of Diagnostic and Interventional Radiology, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany
  • 2Institute for Advanced Study, Technical University of Munich, Garching, Germany
  • 3School of Biomedical Engineering and Imaging Science, King's College London, London, England, United Kingdom
  • 4Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Santiago Metropolitan Region (RM), Chile
  • 5Chair for AI in Healthcare and Medicine, University Hospital rechts der Isar, Technical University of Munich, Munich, Bavaria, Germany
  • 6Department of Computing, Imperial College London, London, England, United Kingdom

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Conventional CMR exams for assessment of cardiac anatomy and tissue characterization require multiple sequential 2D acquisitions under breath-hold in different orientations, in addition to being limited to 1.5 T and 3 T. In this study, we sought to develop a novel 3D motion-compensated freebreathing sequence for comprehensive high-resolution whole-heart assessment of cardiovascular anatomy via simultaneous bright-and black-blood imaging and co-registered T 2 myocardial tissue quantification in a one-click scan at 0.55 T. Good agreement with a spin-echo reference sequence was found in the phantom for T 2 mapping. In-vivo, the proposed research sequence was evaluated in 10 healthy subjects, providing great delineation of cardiac and vascular structures, good visibility of coronary arteries and accurate T 2 parametric mapping in a clinically feasible time of less than 9 minutes.

Keywords: Low-field MRI, 3D whole-heart, simultaneous bright-and black-blood, high-resolution coronary angiography, T2 mapping

Received: 06 Feb 2025; Accepted: 18 Jun 2025.

Copyright: © 2025 Kokhanovskyi, Castillo-Passi, Crabb, Ganter, Littlewood, Kunze, Karampinos, Makowski, Rueckert, Prieto and Botnar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: René M. Botnar, Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, 3580000, Santiago Metropolitan Region (RM), Chile

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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