CASE REPORT article
Front. Cardiovasc. Med.
Sec. Cardio-Oncology
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1572673
This article is part of the Research TopicCase Reports in Cardio-Oncology: 2025View all articles
A Dual Challenge: Navigating Cardiac Leiomyosarcoma and Benign Pulmonary Mass
Provisionally accepted- 1Department of Cardiothoracic surgery, Department of Traditional Chinese Medicine, Chengdu Fifth People's Hospital, Chengdu, China
- 2Department of Pathology Department, Department of Traditional Chinese Medicine, Chengdu Fifth People's Hospital, Chengdu, China
- 3Department of Department of Ultrasound, Department of Traditional Chinese Medicine, Chengdu Fifth People's Hospital, Chengdu, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Leiomyosarcoma is frequently found in the retroperitoneum, mesentery, omentum, uterus, or subcutaneous tissue. However, primary cardiac leiomyosarcoma is rare, and even more uncommon is its coexistence with a benign tumor. We report a case involving a 61-year-old female with a right ventricular outflow tract leiomyosarcoma in conjunction with a benign mass located in the main pulmonary artery.Echocardiography revealed a 2.5 × 2.2 cm isoechoic mass in the right ventricular outflow tract and a 3.8 × 1.8 cm irregular isoechoic mass in the main pulmonary artery. Computed tomography angiography( CTA) indicated a patchy filling defect in a similar location. Initially, pulmonary embolism was considered, however, the possibility of tumors could not be excluded. Given the high risk of mass embolization, we proceeded with emergency surgery. A large, irregular, solid mass was found attached to the wall of the main pulmonary artery, fortunately withoutinvolvement of the pulmonary valve. Exploration of the right ventricular outflow tract uncovered an additional solid, smooth, well-encapsulated mass. Immunohistochemical analysis of the right ventricular outflow tract mass confirmed the presence of tumor cells that were positive forDesmin and smooth muscle actin( SMA), while negative for S-100 and myoglobin, leading to a diagnosis of leiomyosarcoma. For thepulmonary mass, Immunohistochemistry revealed the proliferation of fibrous tissue, mucus degeneration, and calcification within the focal area. The imaging characteristics of cardiac leiomyosarcoma combined with benign pulmonary artery tumors may be misinterpreted asthrombosis, however, surgical resection remains a viable treatment option.
Keywords: Carcinoma, case report, Primary leiomyosarcoma, Benign tumor, cardiac tumor
Received: 07 Feb 2025; Accepted: 29 May 2025.
Copyright: © 2025 Wu, Chen, Yang, Liu, Li, Cheng and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qiulin Chen, Department of Cardiothoracic surgery, Department of Traditional Chinese Medicine, Chengdu Fifth People's Hospital, Chengdu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.