ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. General Cardiovascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1574620
Integrated Risk Factors for Premature Acute Coronary Syndrome: Residual Cholesterol, RDW, and BMI
Provisionally accepted
- Binzhou Medical University Hospital, Binzhou, China
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Introduction: The roles of residual cholesterol (RC), red cell distribution width (RDW), and body mass index (BMI) in premature acute coronary syndrome (ACS) remain underexplored.Aim: This study aimed to investigate the significance of RC, RDW, and BMI in the diagnosis of premature ACS.Methods: A retrospective analysis was conducted on 418 ACS patients at Binzhou Medical University Hospital, categorized into early-onset and late-onset groups. Spearman correlation and multivariate logistic regression were used to evaluate associations. Receiver operating characteristic (ROC) curves assessed the diagnostic performance of RC, RDW, BMI, and their combination.Results: RC and BMI were positively correlated with premature ACS, while RDW was negatively correlated. All three were identified as independent risk factors. A nomogram model highlighted RC as the strongest predictor. The combined model significantly improved diagnostic accuracy, achieving an area under the curve (AUC) of 0.941.Conclusion: RC, RDW, and BMI are independently associated with premature ACS, potentially reflecting inflammatory and metabolic mechanisms. Their combined use enhances diagnostic precision and may support early risk stratification in clinical practice.
Keywords: Acute Coronary Syndrome, Residual cholesterol, Red blood cell distribution width, Body Mass Index, diagnostic value, Risk Assessment
Received: 11 Feb 2025; Accepted: 13 May 2025.
Copyright: © 2025 Liang, Li, Li, Han and Cheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yanli Cheng, Binzhou Medical University Hospital, Binzhou, China
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