CASE REPORT article
Front. Cardiovasc. Med.
Sec. General Cardiovascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1578356
This article is part of the Research TopicExploring Hypertrophic Cardiomyopathy and Cardiac AmyloidosisView all 3 articles
Case Report: Transient Hypertension and Myalgia Following Mavacamten Therapy in a Patient with Hypertrophic Obstructive Cardiomyopathy
Provisionally accepted
- Bethune First Hospital of Jilin University, Changchun, China
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Background: Mavacamten has been demonstrated to be effective in the treatment of hypertrophic obstructive cardiomyopathy (HOCM). However, its hemodynamic impact and extracardiac effects require further characterization. Case Presentation: We report a case of a 68-year-old female diagnosed with severe HOCM who experienced transient hypertension (165/105 mmHg) and myalgia four weeks after mavacamten initiation. Despite a significant reduction in LVOT obstruction (from 64 mmHg to 18 mmHg) and an increase in LVEF to 78%, the patient exhibited a transient hypertensive response that resolved spontaneously within two weeks without intervention. Myalgia was present without corresponding elevations in serum creatine kinase. Conclusions: This case highlights a previously unrecognized transient hypertensive phase associated with myosin inhibition, potentially related to ventriculo-arterial decoupling and peripheral vascular adaptation. Additionally, the dissociation between myalgia and CK elevation suggests alternative skeletal muscle involvement mechanisms. Close blood pressure monitoring and further investigation into the extracardiac effects of mavacamten are warranted.
Keywords: Hypertrophic Cardiomyopathy, Mavacamten, Hypertension, Myalgia, Hemodynamic adaptation
Received: 17 Feb 2025; Accepted: 22 Aug 2025.
Copyright: © 2025 Peng, Fu, Qin, 周 and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
珊珊 周, Bethune First Hospital of Jilin University, Changchun, China
Jian Sun, Bethune First Hospital of Jilin University, Changchun, China
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