Frontiers Corrigendum Template for Authors

Jiayuan Murphy¹Van Le¹Julia Fedorova¹Yi Yang¹Meredith Krause-Hauch¹Kayla Davitt¹Linda Ines Zoungrana¹Mohammad Kasim Fatmi¹Edward J. Lesnefsky²Ji Li¹Di Ren^1*

• ¹University of South Florida, Tampa, Florida, United States
• ²Virginia Commonwealth University, Richmond, Virginia, United States

Corrigendum on: Murphy, J., Le, T. N. V., Fedorova, J., Yang, Y., Krause-Hauch, M., Davitt, K., ... & Ren, D. (2022). The cardiac dysfunction caused by metabolic alterations in Alzheimer's disease. Frontiers in Cardiovascular Medicine, 9, 850538.In the published article, there was an error in the legend for Figure 2A as published. The data represents contractility measurements from isolated cardiomyocytes, not from whole heart tissue, the reported number of biological replicates did not accurately reflect the number of individual cardiomyocytes analyzed per group. The corrected legend appears below.The contractile properties of isolated cardiomyocytes from 5XFAD (6 months) and WT (6 months) hearts. Biological replicates N = 47-68 for each group. P-value determined by two-tailed students t-test.In the published article, there was an error in the legend for Figure 2B as published. The data represents calcium flux measurements from isolated cardiomyocytes, not from whole heart tissue, the reported number of biological replicates did not accurately reflect the number of individual cardiomyocytes analyzed per group. The corrected legend appears below.The transient calcium signal response of the isolated cardiomyocytes from 5XFAD (6 months) and WT (6 months) hearts. Biological replicates N = 24-40 for each group. P-value determined by two-tailed students t-test.The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.In the published article, there was an error in Figue1B R amplitude and PR interval as published. The data in R amplitude represents both technical replicates and biological replicates. Therefore, there are more datapoints than the reported number of biological replicates N=8 per group. The PR interval in Figure 1B was inadvertently duplicated in the final manuscript. This error appears to have been introduced during the final proof submission due to a technical issue when transferring files via different system. The corrected R amplitude and QT interval and its caption (B) Electrocardiography (ECG) showed that 5XFAD mice developed a decreased electrical signal over time with a reduced P wave, QRT complex, and the T wave. Upper: Representative images of ECG parameters. Lower: Quantification of ECG measurements. Biological replicates N = 8 for each group. P-value was determined by two-way ANOVA with Tukey's post-hoc test. appear below. In the published article, there was an error in Figue3C Ctx OCR, Basal Respiration, and Maximal Respiration as published. Ctx OCR was inadvertently duplicated, and this error appears to have been introduced during the final proof submission due to a technical issue when transferring files via different system. The data in Basal Respiration and Maximal Respiration represent both biological dependent replicates (Cortex tissues) and biological independent replicates (different mice). Therefore, there are more datapoints than the reported number of biological replicates N=6 per group. The corrected Figue3C and its caption (C) Mitochondrial stress assay examined the mitochondrial oxidative phosphorylation (OXPHOS) complexes activity in the cortex of 5XFAD (6 months) and WT (6 months) mice demonstrated by measuring the oxygen consumption rate (OCR). N = 6 for each group. P-value determined by two-tailed students ttest. appear below.