ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Heart Valve Disease
Clinical Study on Postoperative Inflammation and Cardiac Function Improvement Following Valve Replacement Surgery
Provisionally accepted
- 1Department of Cardiology, Yancheng No.1 People’s Hospital, Yancheng, China
- 2Zhongshan Hospital, Fudan University, Shanghai, Shanghai Municipality, China
- 3905th Hospital of the PLA Navy, Shanghai, China
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Word count: 175 Objective: To investigate the impact of C-reactive protein (CRP) levels measured on the third day after valve replacement surgery on cardiac function recovery at three months postoperatively and to analyze its association with other clinical risk factors, thereby providing reference data for perioperative management.A retrospective analysis was conducted on 188 patients who underwent valve replacement surgery. Patients were divided into a high-inflammation group (100 cases) and a low-inflammation group (88 cases) based on CRP levels on postoperative day 3. Baseline characteristics, preoperative BNP levels, LVEF, intraoperative parameters, postoperative inflammation levels, and complications were compared between the two groups. Postoperative LVEF, BNP levels at 1 week and 3 months, and total hospital stay were evaluated. Univariate and multivariate logistic regression analyses were used to identify factors influencing cardiac function improvement at 3 months in the high inflammation group. Data were analyzed using SPSS, with a P-value < 0.05 considered statistically significant.The high inflammation group showed a lower cardiac function improvement rate at 3 months (71% vs. 85.2%, P=0.019) and a longer hospital stay (19 [17,21] vs.
Keywords: Valve replacement surgery, Postoperative inflammation, C-Reactive Protein, cardiac function recovery, Risk factors
Received: 27 Feb 2025; Accepted: 12 Nov 2025.
Copyright: © 2025 Li, Xu, He, Chao and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Rong Zhou, 19851559803@163.com
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