ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1584548
This article is part of the Research TopicDrug-Eluting Balloons in Coronary InterventionsView all articles
Evaluation of FFR and CPET in patients with de novo coronary chronic total occlusion treated with DCB versus DES
Provisionally accepted
Hengdao Liu1
Lingli Guo2
Xi Zhao1
Ting Liu1Chenyang Gao3Jihao Duan4Dongfeng Wang4Junwei Zhao5Yuzhen Wei1Ruipeng Song2*Hailong Tao1*- 1First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- 2Henan Provincial Third People's Hospital, Zhengzhou, Henan Province, China
- 3Neihuang People's Hospital, Anyang, China
- 4Third People's Hospital of Luohe, Luohe, China
- 5Yexian People’s Hospital, Pingdingshan, China
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Background: Drug-coated balloon (DCB) is a novel therapeutic strategy for de novo coronary chronic total occlusion (CTO). However, fractional flow reserve (FFR), a key indicator of evaluating coronary function, and cardiopulmonary exercise testing (CPET), an important indicator of cardiopulmonary function, are rarely reported for evaluating the effectiveness of DCB in CTO lesions.In this retrospective study, 100 patients were enrolled and classified into the DCB group (n=48) and the drug-eluting stent (DES) group (n=52). All patients underwent coronary angiography (CAG) immediately after PCI and during follow-up. Some patients underwent FFR measurement (n = 64) or CPET (n = 56) at follow-up. There was no significant difference in baseline clinical characteristics between the two groups.Compared with the DES group, the DCB group had a significantly smaller late lumen loss (LLL) (P < 0.05). And there was no significant difference in the proportion of FFR values ≥ 0.90 between the two groups at follow-up. Similarly, there was also no statistically significant difference in the CPET parameters between the two groups (P > 0.05). In addition, the incidence of MACE (major adverse cardiovascular events) showed no statistical difference during hospitalization and follow-up between the two groups (P > 0.05).Conclusions: DCB treatment for de novo CTO lesions yields FFR and CPET results comparable to DES, with even smaller LLL. This result provides a new approach for the treatment of de novo CTO lesions.
Keywords: coronary chronic total occlusion, Drug-coated balloon, Fractional flow reserve, Cardiopulmonary exercise testing, Drug-eluting stent
Received: 27 Feb 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 Liu, Guo, Zhao, Liu, Gao, Duan, Wang, Zhao, Wei, Song and Tao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ruipeng Song, Henan Provincial Third People's Hospital, Zhengzhou, Henan Province, China
Hailong Tao, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
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