ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Cardiovascular Epidemiology and Prevention
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1586731
Clinical Characteristics and Influencing Factors of Cardiovascular Comorbidities in Psoriasis
Provisionally accepted
- 1Beijing University of Chinese Medicine, Beijing, Beijing Municipality, China
- 2Department of Dermatology, China-Japan Friendship Hospital, Beijing, China
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Psoriasis is a chronic inflammatory skin disorder with recognized systemic implications, including an elevated risk of cardiovascular disease (CVD). This retrospective cohort study aimed to characterize the clinical profile of psoriasis patients with cardiovascular comorbidities and identify factors contributing to the development of CVD in this population. Data were collected from 320 psoriasis patients, with 130 (40.6%) diagnosed with CVD. Our findings revealed that patients with psoriasis and CVD were older, had a longer duration of disease, and exhibited more severe psoriasis compared to those without CVD. Additionally, they demonstrated a higher burden of traditional cardiovascular risk factors, including hypertension, diabetes, and dyslipidemia. Multivariable logistic regression identified several independent predictors of CVD in psoriasis, including age, psoriasis duration, disease severity (measured by the Psoriasis Area and Severity Index), hypertension, diabetes, and elevated C-reactive protein. These results highlight the interplay between psoriasis and cardiovascular health and underscore the need for integrated management strategies to mitigate cardiovascular risk in this patient population. Future research should explore whether targeted anti-inflammatory therapies can reduce cardiovascular outcomes in psoriasis patients.
Keywords: Psoriasis, cardiovascular disease, comorbidities, Inflammation, metabolic syndrome, systemic inflammation
Received: 03 Mar 2025; Accepted: 08 Sep 2025.
Copyright: © 2025 Li, Gu, Xiang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoyan Zhang, osvz26@163.com
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