MINI REVIEW article
Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1589121
This article is part of the Research TopicNovel Role and Mechanisms of Inflammation in Myocardial InfarctionView all 4 articles
The Relationship between Hematological Parameters and Coronary Angiographic Lesions
Provisionally accepted
Thadzia Maria de Brito Ramos
José Gildo de Moura Monteiro Júnior*Veridiana Câmara FurtadoDário Celestino Sobral Filho- PROCAPE, Universidade de Pernambuco, Recife, Pernambuco, Brazil
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Atherosclerosis is the most important etiology of acute myocardial infarction, which is considered an inflammatory disease with specific cellular and molecular responses.Research has linked hematological variables as biomarkers of the severity of coronary artery disease. Recent study points to nucleated red blood cells (NRBCs), neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) with a potential role as a laboratory model or hematological score for in-hospital surveillance.These atherosclerotic plaques are classified based on the scoring system and it was mentioned as a tool to grade the complexity of coronary artery disease represented by the SYNTAX score. However, there is an open field for research to explain the complex inflammatory mechanism of these atherosclerotic plaques. Research has shown that the bone marrow releases young and immature cells into the systemic circulation in the presence of inflammatory processes, such as coronary atherosclerotic disease, which are actively aggregating and, consequently, forming thrombotic plaques. This mini review article aims to demonstrate the relationship between these hematological parameters and coronary angiographic lesions as potential in-hospital prognostic tools for patients with acute myocardial infarction. This expressive relationship between these hematological biomarkers and coronary atherosclerotic plaques may be targets, in addition to prognostic scores, of future therapeutic interventions.
Keywords: hematological parameters, Nucleated red blood cells, Neutrophil to lymphocyte ratio, mean platelet volume, coronary angiographic lesions, Syntax score, prognostic
Received: 06 Mar 2025; Accepted: 01 Aug 2025.
Copyright: © 2025 Ramos, Monteiro Júnior, Furtado and Sobral Filho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: José Gildo de Moura Monteiro Júnior, PROCAPE, Universidade de Pernambuco, Recife, 74970-240, Pernambuco, Brazil
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