CASE REPORT article
Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1591179
This article is part of the Research TopicCase Reports in Coronary Artery Disease: 2025View all 5 articles
Lenalidomide-Induced Type II Kounis Syndrome: A Case Report
Provisionally accepted
Ruihan Hu
Guoxiang He*- Department of Cardiovascular Medicine, Guiqian International General Hospital, Guiyang, Guizhou Province, China
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Kounis syndrome is an allergic myocardial ischemia syndrome triggered by various factors. Herein, we presented a case of a patient with Multiple Myeloma who developed chest pain as a result of lenalidomide use. The patient’s electrocardiogram (ECG) revealed ST-segment depression, along with elevated troponin I and eosinophils levels. Emergency coronary angiography identified thrombosis in the middle segment of the anterior descending branch of the left coronary artery. Previous case reports have linked lenalidomide chemotherapy to myocarditis as the primary form of myocardial damage. This case marks the first documented occurrence of myocardial infarction attributed to lenalidomide, highlighting a previously unrecognized aspect of its cardiotoxic profile.
Keywords: Myocardial Infarction, Kounis syndrome, Lenalidomide, allergy, Interventional treatment
Received: 10 Mar 2025; Accepted: 31 May 2025.
Copyright: © 2025 Hu and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Guoxiang He, Department of Cardiovascular Medicine, Guiqian International General Hospital, Guiyang, Guizhou Province, China
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