SYSTEMATIC REVIEW article
Front. Cardiovasc. Med.
Sec. Hypertension
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1593481
Correlation analysis of systemic immune inflammation index with the occurrence and clinical outcomes of hypertension: A systematic review and meta-analysis
Provisionally accepted
- 1Heilongjiang University of Chinese Medicine, Harbin, China
- 2First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
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Objective: This systematic review and meta-analysis aimed to examine the link between the systemic immune inflammation index (SII) and the incidence and clinical outcomes of hypertension (HTN). Methods: Studies on the link association SII levels with the incidence and prognosis of HTN were retrieved in PubMed, Embase, Web of Science, and Cochrane Library databases. The standardized mean difference (SMD) was employed to discuss the stability of the results and potential sources of heterogeneity. The meta-analysis was performed with Review Manager 5.4.1 and STATA 15.0 software. Results: In total, 19 articles were included, covering 187,195 patients. The results demonstrated that elevated SII was associated with the incidence of HTN (continuous variable: SMD=1.22, 95% confidence interval [CI]: 0.56, 1.89, P=0.000; categorical variable: odds ratio [OR]=1.14, 95% CI: 1.08, 1.20, P=0.000). Furthermore, SII was also closely linked to the prognosis of HTN patients. Subgroup analyses based on study design, sample size, region, and mean age revealed that high SII levels were associated with the incidence and prognosis of HTN. Compared to the low SII group, the incidence of HTN was greater in individuals with high SII (continuous: SMD=1.22, 95% CI: 0.56, 1.89, P=0.000; categorical: OR=1.14, 95% CI: 1.08, 1.20, P=0.000). HTN patients in the high SII group had higher rates of mortality, major cardiovascular adverse events, carotid intima-media thickness, and asymptomatic organ damage than those in the low SII group. Conclusion: SII is potentially associated with the risk and prognosis of HTN, and is likely to become a valuable inflammatory marker for preventing HTN. In light of the inherent limitations of this study, more prospective, large-scale studies are necessary to confirm the findings of this study.
Keywords: NEUT count * PLT count / LYM count, Hypertension, The occurrence of hypertension, Prognosis for patients with hypertension, Meta-analysis
Received: 18 Mar 2025; Accepted: 16 Oct 2025.
Copyright: © 2025 Sun, Fu, Yang, Zhao, Zhao and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yabin Zhou, 18004667550@163.com
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