ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Cardiovascular Metabolism
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1597749
This article is part of the Research TopicCardiovascular Anthropometry For Large Scale Population Studies Volume IIView all 9 articles
Association between the atherogenic index of plasma, body mass index, and cardiovascular diseases in Chinese middle and old-aged adults: a mediation analysis
Provisionally accepted
- 1Department of Cardiovascular Medicine, the First Affiliated Hospital of Xi’an Jiaotong University, Xian, China
- 2Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi’an, Shaanxi, China
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Background Evidence has emerged that suggests the atherogenic index of plasma (AIP), as determined by blood lipid levels, is a valuable predictor of the onset of cardiovascular diseases. The correlation between AIP and cardiovascular diseases may be facilitated by body mass index (BMI), as atherosclerosis is prevalent in overweight and obese populations. In order to assess the combined predictive value of the AIP and BMI in predicting outcomes associated with cardiovascular diseases, this study sought to determine if BMI mediates the relationship between the AIP and cardiovascular disease risk. Methods Participants in this study were those who were without cardiovascular diseases at baseline and were members of the China Health and Retirement Longitudinal Study (CHARLS). We performed adjusted regression analysis and mediation. AIP was calculated using the logarithm of the ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C). The estimated body weight and height were used to calculate the BMI. Results This study included 5468 participants. Cardiovascular diseases were highly linked with both BMI and AIP. In contrast to those with a lower AIP (median level) and BMI <24, those with an elevated AIP and increased BMI presented a higher risk for developing cardiovascular conditions (HR: 1.789; 95% CI: 1.491–2.147). Additionally, about 30.57% of the connection between AIP and cardiovascular diseases was strongly mediated by BMI. Conclusions Among Chinese adults in their middle and advanced years, the AIP and BMI jointly have been associated to a higher risk of cardiovascular diseases, and BMI could serve as a mediator in this connection.
Keywords: Atherogenic index of plasma, Body Mass Index, Cardiovascular Diseases, CHARLS, Mediation analysis
Received: 21 Mar 2025; Accepted: 10 Oct 2025.
Copyright: © 2025 Xu, Liu, Yang, Zhang, Fan, Xu, Zhou and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Juan Zhou, 1306899042@qq.com
Zuyi Yuan, zuyiyuan2024@163.com
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