ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Intensive Care Cardiovascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1599152
This article is part of the Research TopicAtrial Fibrillation: Selection of Management Strategy and Evaluation of Outcomes -Volume IIView all 4 articles
Predictive value of inflammatory burden index for new-onset atrial fibrillation in STEMI patients
Provisionally accepted
- 1First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China
- 2The First People’s Hospital of Lianyungang, Lianyungang, Jiangsu Province, China
- 3Second Affiliated Hospital of Soochow University, Suzhou, China
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Background The inflammatory burden index (IBI) is a novel and useful inflammatory marker. However, the association between IBI and new-onset atrial fibrillation (NOAF) in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. This study focuses on exploring the predictive ability of IBI for NOAF after percutaneous coronary intervention (PCI) in STEMI patients. Materials and Methods This study is a single-center retrospective observational study. Patients diagnosed with STEMI and undergoing primary PCI between October 2022 and February 2025 were continuously enrolled. All enrolled patients received continuous electrocardiogram (ECG) monitoring (> 72h) and were grouped according to whether NOAF occurred during hospitalization. Logistic regression analysis was used to identify potential risk factors for NOAF. Meanwhile, restricted cubic spline (RCS) analysis was employed to thoroughly investigate the possible dose-response relationship between IBI and NOAF. Results A total of 696 STEMI patients were finally included in this study. The incidence of NOAF during hospitalization was 62/696 (8.9%). After adjusting for potential confounding factors, the results of multivariate logistic regression analysis showed that left ventricular ejection fraction (OR = 0.928, 95% CI: 0.895 - 0.962), age (OR = 1.048, 95% CI: 1.022 - 1.075), and IBI (OR = 1.007, 95% CI: 1.003 - 1.011) were independent factors for NOAF in STEMI patients (P < 0.05). RCS results suggested that there was a non-linear dose-response relationship between IBI and NOAF. After integrating IBI, the ability of the new model to predict NOAF was significantly improved (NRI = 0.617, 95% CI: 0.360 - 0.873, P < 0.01; IDI = 0.026, 95% CI: 0.007 - 0.046, P = 0.008). Conclusions: Elevated IBI is an independent risk factor for NOAF after PCI in STEMI patients. Integrating IBI can improve the risk stratification for NOAF in STEMI patients.
Keywords: Inflammation response, inflammatory burden index, Atrial Fibrillation, ST-segment elevation myocardial infarction, risk stratification
Received: 24 Mar 2025; Accepted: 04 Sep 2025.
Copyright: © 2025 Liu, Tao, Li, Li, Yin and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiayu Yin, Second Affiliated Hospital of Soochow University, Suzhou, China
Lei Zhou, First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China
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